RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene

Stable Identifier
R-HSA-1368087
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

As inferred from mouse, RORA binds RRE DNA elements and recruits the coactivators PGC-1alpha (PPARGC1A), p300 (EP300, a histone acetylase), and NRIP1. Activation of BMAL1 (ARNTL) expression by ROR-alpha (RORA) is inferred from mouse. In mouse, Rora together with coactivators Ep300 and Ppargc1a bind the promoter of Bmal1 and activate transcription.

Literature References
PubMed ID Title Journal Year
21628546 Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140)

Parker, MG, Spinella, MJ, Dunlap, JC, Loros, JJ, Poliandri, AH, Gamsby, JJ, Christian, M

J. Biol. Rhythms 2011
Participants
Input
Output
Participates
as an event of
Inferred From
Rora, Ep300, Ppargc1a bind Arntl (Bmal1) gene (Mus musculus)
Authored
May, B  (2011-06-22)
Reviewed
Delaunay, F  (2012-01-28)
Created
May, B  (2011-06-30)
Cite Us!