RORA activates gene expression

Stable Identifier
R-HSA-1368082
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane, endoplasmic reticulum membrane
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RORA activates gene expression
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As inferred from mouse, RORA binds ROR elements (ROREs) in DNA and recruits the coactivators PPARGC1A (PGC-1alpha) and p300 (EP300, a histone acetylase) to activate transcription.

Literature References
PubMed ID Title Journal Year
7926749 Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors

Giguère, V, Tini, M, Flock, G, Ong, E, Evans, RM, Otulakowski, G

Genes Dev 1994
Participants
Events
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as an event of
Authored
May, B  (2011-06-22)
Reviewed
Delaunay, F  (2012-01-28)
Created
May, B  (2011-06-30)
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