Expression of SREBF1 (SREBP1)

Stable Identifier
R-HSA-1368081
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, endoplasmic reticulum membrane
ReviewStatus
5/5
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Expression of SREBF1 (SREBP1)
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As inferred from mouse, RORA (ROR-alpha) enhances expression of SREBP1 (SREBF1). The SREBF1 (SREBP1) gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
Literature References
PubMed ID Title Journal Year
8156598 SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

Brown, MS, Wang, X, Goldstein, JL, Hua, X, Sato, R

Cell 1994
9062340 Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

Brown, MS, Goldstein, JL, Horton, JD, Shimano, H, Shimomura, I

J Clin Invest 1997
8060328 Sterol mediated regulation of SREBP-1a,1b,1c and SREBP-2 in cultured human cells

Yazaki, Y, Kawabe, Y, Ohba, Y, Itakura, H, Wada, Y, Nabata, H, Suzuki, T, Honda, M, Matsumoto, A, Endo, A

Biochem Biophys Res Commun 1994
8402897 SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

Brown, MS, Wang, X, Yokoyama, C, Goldstein, JL, Hua, X, Admon, A, Briggs, MR, Wu, J

Cell 1993
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RORA:EP300:SREBF1 gene [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Srebf1 (Mus musculus)
Authored
May, B  (2011-06-22)
Reviewed
Delaunay, F  (2012-01-28)
Created
May, B  (2011-06-30)
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