NR1D1 (REV-ERBA) represses gene expression

Stable Identifier
R-HSA-1368071
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Pathway
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Homo sapiens
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REV-ERBA binds DNA elements very similar to those bound by the transcription activator RORA. RORAREV-ERBA bound to DNA and heme recruits the corepressors NCoR and HDAC3 to repress transcription. Thus REV-ERBA and RORA appear to compete to repress or activate genes, repectively.

Literature References
PubMed ID Title Journal Year
20581824 Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction

Phelan, CA, Gampe RT, Jr, Lambert, MH, Parks, DJ, Montana, V, Bynum, J, Broderick, TM, Hu, X, Williams, SP, Nolte, RT, Lazar, MA

Nat Struct Mol Biol 2010
20414452 Nuclear receptor Rev-erbalpha: a heme receptor that coordinates circadian rhythm and metabolism

Yin, L, Wu, N, Lazar, MA

Nucl Recept Signal 2010
18006707 Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways

Yin, L, Wu, N, Curtin, JC, Qatanani, M, Szwergold, NR, Reid, RA, Waitt, GM, Parks, DJ, Pearce, KH, Wisely, GB, Lazar, MA

Science 2007
18037887 Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta

Raghuram, S, Stayrook, KR, Huang, P, Rogers, PM, Nosie, AK, McClure, DB, Burris, LL, Khorasanizadeh, S, Burris, TP, Rastinejad, F

Nat Struct Mol Biol 2007
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