Ubiquitination of p130 (RBL2) by SCF (Skp2)

Stable Identifier
R-HSA-1363331
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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As quiescent G0 cells reenter the cell cycle, p130 (RBL2) is phosphorylated by CDK4/6. This phosphorylated p130 (RBL2) binds ubiquitin ligase SCF (Skp2) in complex with Cks1, and is subsequently ubiquitinated and degraded similarly to p27, which is another target of SCF (Skp2).

Literature References
PubMed ID Title Journal Year
12435635 The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2)

Tedesco, D, Lukas, J, Reed, SI

Genes Dev 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created