Reactome | Ubiquitination of p130 (RBL2) by SCF (Skp2)

Ubiquitination of p130 (RBL2) by SCF (Skp2)

Stable Identifier

R-HSA-1363331

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Ubiquitination of p130 (RBL2) by SCF (Skp2)

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As quiescent G0 cells reenter the cell cycle, p130 (RBL2) is phosphorylated by CDK4/6. This phosphorylated p130 (RBL2) binds ubiquitin ligase SCF (Skp2) in complex with Cks1, and is subsequently ubiquitinated and degraded similarly to p27, which is another target of SCF (Skp2).

Literature References

PubMed ID	Title	Journal	Year
12435635	The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2) Lukas, J, Reed, SI, Tedesco, D	Genes Dev	2002