Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex

Stable Identifier
R-HSA-1363328
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex
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Phosphorylated p130 (RBL2) binds SCF (Skp2) ubiquitin ligase in complex with Cks1. Phosphorylation of p130 (RBL2) serine residue S672 by CDK4/6 is critical for this interaction.
Literature References
PubMed ID Title Journal Year
12435635 The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2)

Lukas, J, Reed, SI, Tedesco, D

Genes Dev 2002
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Orthologous Events
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Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Gallus gallus)
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Mus musculus)
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Rattus norvegicus)
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Sus scrofa)
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2011-06-14)
Reviewed
MacPherson, D  (2011-08-25)
Created
Orlic-Milacic, M  (2011-06-14)
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