p107 (RBL1) binds CyclinE/A:CDK2

Stable Identifier
R-HSA-1363314
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p107 (RBL1) binds CyclinE/A:CDK2
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p107 (RBL1) is able to bind complexes of CDK2 with either cyclin A or cyclin E, through cyclin-binding LFG motif in the pocket domain, which is conserved in p130 (RBL2) and p21/WAF1/Cip1 family of cyclin-dependent kinase inhibitors. In addition to the LFG motif, the amino terminal sequence conserved in the p107 (RBL1) and p130 (RBL2) is needed for inhibition of CDK2 kinase activity. Presence of E2F is not required for this interaction.
Literature References
PubMed ID Title Journal Year
9199292 p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity

Dynlacht, BD, Sánchez, I, Woo, MS

Mol Cell Biol 1997
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Orthologous Events
p107 (RBL1) binds CyclinE/A:CDK2 (Bos taurus)
p107 (RBL1) binds CyclinE/A:CDK2 (Caenorhabditis elegans)
p107 (RBL1) binds CyclinE/A:CDK2 (Canis familiaris)
p107 (RBL1) binds CyclinE/A:CDK2 (Danio rerio)
p107 (RBL1) binds CyclinE/A:CDK2 (Dictyostelium discoideum)
p107 (RBL1) binds CyclinE/A:CDK2 (Drosophila melanogaster)
p107 (RBL1) binds CyclinE/A:CDK2 (Gallus gallus)
p107 (RBL1) binds CyclinE/A:CDK2 (Mus musculus)
p107 (RBL1) binds CyclinE/A:CDK2 (Rattus norvegicus)
p107 (RBL1) binds CyclinE/A:CDK2 (Sus scrofa)
p107 (RBL1) binds CyclinE/A:CDK2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2011-06-14)
Reviewed
MacPherson, D  (2011-08-25)
Created
Orlic-Milacic, M  (2011-06-14)
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