Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix

Stable Identifier
R-HSA-1362417
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix
ReviewStatus
5/5
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Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix
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As inferred from biochemical studies in yeast and phenotypic studies in mouse, Mitoferrin-1 (SLC25A37) and Mitoferrin-2 (SLC25A28) transport ferrous iron across the inner mitochondrial membrane. Mitoferrin-1 is essential for maintaining mitochondrial iron uptake in developing erythroid cells; mitoferrin-2 is ubiquitously expressed. Defects in Mitoferrin-1 and Mitoferrin-2 cause a reduction in mitochondrial iron acquisition and biogenesis of iron-sulfur clusters and heme.
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Catalyst Activity

ferrous iron transmembrane transporter activity of Mitoferrin1,2 [mitochondrial inner membrane]

Physical Entity
Mitoferrin1,2 [mitochondrial inner membrane] (Homo sapiens)
Activity
ferrous iron transmembrane transporter activity (GO:0015093)
Inferred From
MRS3,4 Transports Iron Across the Mitochondrial Inner Membrane (Saccharomyces cerevisiae)
Mitoferrin Transports Iron Across the Mitochondrial Inner Membrane (Mus musculus)
Cross References
Rhea
Authored
May, B  (2011-06-04)
Lill, R  (2012-09-24)
Reviewed
Tong, WH  (2012-10-12)
Rouault, TA  (2012-10-12)
Created
May, B  (2011-06-09)
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