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PXLP-K258-NFS1-1 [mitochondrial matrix]
Stable Identifier
R-HSA-1362396
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
NFS1, mitochondrial (ISCS), Cysteine desulfurase, mitochondrial, NFS1_HUMAN, NSF1 isoform 1
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
Maturation of TCA enzymes and regulation of TCA cycle (Homo sapiens)
Transfer of Fe-S clusters to SDHB (Homo sapiens)
FXN:ISD11:NFS1:ISCU [mitochondrial matrix] (Homo sapiens)
PXLP-K258-NFS1-1 [mitochondrial matrix] (Homo sapiens)
FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Homo sapiens)
PXLP-K258-NFS1-1 [mitochondrial matrix] (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex III assembly (Homo sapiens)
2Fe-2S is inserted in UQCRFS1 (Homo sapiens)
FXN:ISD11:NFS1:ISCU [mitochondrial matrix] (Homo sapiens)
PXLP-K258-NFS1-1 [mitochondrial matrix] (Homo sapiens)
FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Homo sapiens)
PXLP-K258-NFS1-1 [mitochondrial matrix] (Homo sapiens)
Mitochondrial iron-sulfur cluster biogenesis (Homo sapiens)
FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Homo sapiens)
2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix] (Homo sapiens)
PXLP-K258-NFS1-1 [mitochondrial matrix] (Homo sapiens)
FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Homo sapiens)
PXLP-K258-NFS1-1 [mitochondrial matrix] (Homo sapiens)
PXLP-K258-NFS1-1 [mitochondrial matrix] (Homo sapiens)
Frataxin binds iron (Homo sapiens)
2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix] (Homo sapiens)
PXLP-K258-NFS1-1 [mitochondrial matrix] (Homo sapiens)
FXN:ISD11:NFS1:ISCU [mitochondrial matrix] (Homo sapiens)
PXLP-K258-NFS1-1 [mitochondrial matrix] (Homo sapiens)
General
By analogy with yeast Hfs1, human NFS1 probably has an N-terminal transit peptide that is removed by mitochondrial processing peptidase. The cleavage site is unknown.
External Reference Information
External Reference
UniProt:Q9Y697-1 NFS1
Gene Names
NFS1, NIFS, HUSSY-08
Other Identifiers
11718117_a_at
11748839_a_at
11750044_a_at
11751828_x_at
1554321_3p_a_at
1554321_PM_a_at
1554321_a_at
16918832
218455_PM_at
218455_at
3904190
3904191
3904192
3904193
3904194
3904195
3904198
3904199
3904201
3904202
3904204
3904205
3904207
3904209
3904211
3904212
3904213
3904214
3904215
3904216
3904217
3904218
3904219
56240_at
8065992
9054
A_23_P102842
A_33_P3298634
GE62340
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005759
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006777
GO:0006790
GO:0016226
GO:0016740
GO:0018283
GO:0030170
GO:0031071
GO:0036211
GO:0042803
GO:0043226
GO:0043545
GO:0044571
GO:0044572
GO:0046872
GO:0051536
GO:0099128
GO:1990229
HMNXSV003041758
ILMN_1703079
ILMN_1761314
PH_hs_0011504
TC20001559.hg
TC20001763.hg
g10864078_3p_at
Participates
as a component of
2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix] (Homo sapiens)
FXN:ISD11:NFS1:ISCU [mitochondrial matrix] (Homo sapiens)
FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (Homo sapiens)
Inferred To
nfs1 [mitochondrial matrix]
(Danio rerio)
nfs1 [mitochondrial matrix]
(Xenopus tropicalis)
NFS1 [mitochondrial matrix]
(Bos taurus)
NFS1 [mitochondrial matrix]
(Canis familiaris)
NFS1 [mitochondrial matrix]
(Sus scrofa)
PXLP-K258-NFS1-1 [mitochondrial matrix]
(Dictyostelium discoideum)
PXLP-K258-NFS1-1 [mitochondrial matrix]
(Drosophila melanogaster)
PXLP-K258-NFS1-1 [mitochondrial matrix]
(Gallus gallus)
PXLP-K258-NFS1-1 [mitochondrial matrix]
(Mus musculus)
PXLP-K258-NFS1-1 [mitochondrial matrix]
(Plasmodium falciparum)
PXLP-K258-NFS1-1 [mitochondrial matrix]
(Rattus norvegicus)
PXLP-K258-NFS1-1 [mitochondrial matrix]
(Saccharomyces cerevisiae)
PXLP-K258-NFS1-1 [mitochondrial matrix]
(Schizosaccharomyces pombe)
nfs-1 [mitochondrial matrix]
(Caenorhabditis elegans)
Modified Residues
Name
N6-pyridoxal phosphate-L-lysine at 258
Coordinate
258
PsiMod Name
N6-pyridoxal phosphate-L-lysine [MOD:00128]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.
Cross References
RefSeq
NP_066923.3
,
NP_001185918.1
OpenTargets
ENSG00000244005
GeneCards
Q9Y697
HPA
ENSG00000244005-NFS1
Ensembl
ENST00000374085
,
ENSP00000363198
,
ENST00000397425
,
ENSP00000380570
,
ENST00000541387
,
ENSP00000363205
,
ENSG00000244005
,
ENSP00000440897
,
ENST00000374092
PRO
Q9Y697
Pharos - Targets
Q9Y697
Orphanet
22802
PDB
5WKP
,
6WI2
,
5WGB
,
6W1D
,
6UXE
,
5WLW
,
5USR
,
6NZU
,
6WIH
,
5KZ5
,
7RTK
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