Reactome | p130 (RBL2) associates with MuvB to form DREAM complex

p130 (RBL2) associates with MuvB to form DREAM complex

Stable Identifier

R-HSA-1362261

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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p130 (RBL2) associates with MuvB to form DREAM complex

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In G0 and early G1, p130 (RBL2) bound to E2F4 or E2F5 and DP1 or DP2 associates with the MuvB complex, consisting of LIN9, LIN37, LIN52, LIN54 and RBBP4 to form evolutionarily conserved DREAM complex. Phosphorylation of LIN52 on serine residue S28 is critical for association of MuvB complex with p130 (RBL2).

Literature References

PubMed ID	Title	Journal	Year
17531812	Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence DeCaprio, JA, Washburn, MP, Swanson, SK, Zhu, X, Florens, LA, Chen, R, Litovchick, L, Liu, XS, Sadasivam, S, Velmurugan, S	Mol Cell	2007
21498570	DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly DeCaprio, JA, Washburn, MP, Swanson, SK, Florens, LA, Litovchick, L	Genes Dev	2011