Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Ubiquitinated RNF41 binds P-USP8
Stable Identifier
R-HSA-1358797
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
Downregulation of ERBB2 signaling (Homo sapiens)
Downregulation of ERBB2:ERBB3 signaling (Homo sapiens)
Ubiquitinated RNF41 binds P-USP8 (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Ubiquitinated RNF41 binds deubiquitinating enzyme USP8, previously activated by phosphorylation on threonine residue T945.
Literature References
PubMed ID
Title
Journal
Year
17210635
Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1
Carraway KL, 3rd
,
Cao, Z
,
Sweeney, C
,
Wu, X
,
Yen, L
Mol Cell Biol
2007
Participants
Input
p-T945-USP8 [cytosol]
(Homo sapiens)
Ub-RNF41 [cytosol]
(Homo sapiens)
Output
Ub-RNF41:p-USP8 [cytosol]
(Homo sapiens)
Participates
as an event of
Downregulation of ERBB2:ERBB3 signaling (Homo sapiens)
Orthologous Events
Ubiquitinated RNF41 binds P-USP8 (Bos taurus)
Ubiquitinated RNF41 binds P-USP8 (Dictyostelium discoideum)
Ubiquitinated RNF41 binds P-USP8 (Drosophila melanogaster)
Ubiquitinated RNF41 binds P-USP8 (Gallus gallus)
Ubiquitinated RNF41 binds P-USP8 (Mus musculus)
Ubiquitinated RNF41 binds P-USP8 (Rattus norvegicus)
Ubiquitinated RNF41 binds P-USP8 (Sus scrofa)
Authored
Orlic-Milacic, M (2011-11-04)
Reviewed
Neckers, LM (2011-11-11)
Xu, W (2011-11-11)
Created
Orlic-Milacic, M (2011-06-02)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text