Phosphorylation of USP8 by P-AKT

Stable Identifier
R-HSA-1358791
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated AKT phosphorylates USP8, thereby stabilizing it and allowing it to deubiquitinate NRDP1, which results in increased NRDP1 level and downregulation of ERBB3. This represents a negative feedback loop in ERBB3-mediated signaling.

Literature References
PubMed ID Title Journal Year
17210635 Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1

Cao, Z, Wu, X, Yen, L, Sweeney, C, Carraway KL, 3rd

Mol Cell Biol 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created