Activated AKT phosphorylates USP8, thereby stabilizing it and allowing it to deubiquitinate NRDP1, which results in increased NRDP1 level and downregulation of ERBB3. This represents a negative feedback loop in ERBB3-mediated signaling.
Cao, Z, Wu, X, Yen, L, Sweeney, C, Carraway KL, 3rd
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