Phosphorylation of USP8 by P-AKT

Stable Identifier
R-HSA-1358791
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Phosphorylation of USP8 by P-AKT
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Activated AKT phosphorylates USP8, thereby stabilizing it and allowing it to deubiquitinate NRDP1, which results in increased NRDP1 level and downregulation of ERBB3. This represents a negative feedback loop in ERBB3-mediated signaling.
Literature References
PubMed ID Title Journal Year
17210635 Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1

Cao, Z, Wu, X, Yen, L, Sweeney, C, Carraway KL, 3rd

Mol Cell Biol 2007
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]

Physical Entity
p-T,p-S-AKT [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of USP8 by P-AKT (Danio rerio)
Phosphorylation of USP8 by P-AKT (Drosophila melanogaster)
Phosphorylation of USP8 by P-AKT (Gallus gallus)
Phosphorylation of USP8 by P-AKT (Mus musculus)
Phosphorylation of USP8 by P-AKT (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-06-02)
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