Phosphorylation of USP8 by P-AKT

Stable Identifier
R-HSA-1358791
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Phosphorylation of USP8 by P-AKT
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Activated AKT phosphorylates USP8, thereby stabilizing it and allowing it to deubiquitinate NRDP1, which results in increased NRDP1 level and downregulation of ERBB3. This represents a negative feedback loop in ERBB3-mediated signaling.

Literature References
PubMed ID Title Journal Year
17210635 Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1

Cao, Z, Wu, X, Yen, L, Sweeney, C, Carraway KL, 3rd

Mol Cell Biol 2007
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
Physical Entity
p-T,p-S-AKT [cytosol]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
Phosphorylation of USP8 by P-AKT (Canis familiaris)
Phosphorylation of USP8 by P-AKT (Danio rerio)
Phosphorylation of USP8 by P-AKT (Dictyostelium discoideum)
Phosphorylation of USP8 by P-AKT (Gallus gallus)
Phosphorylation of USP8 by P-AKT (Mus musculus)
Phosphorylation of USP8 by P-AKT (Rattus norvegicus)
Phosphorylation of USP8 by P-AKT (Saccharomyces cerevisiae)
Phosphorylation of USP8 by P-AKT (Schizosaccharomyces pombe)
Phosphorylation of USP8 by P-AKT (Sus scrofa)
Phosphorylation of USP8 by P-AKT (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-06-02)