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GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers
Stable Identifier
R-HSA-1306969
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
GRB2 events in ERBB2 signaling (Homo sapiens)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
GRB2:SOS1 complex binds to phosphorylated tyrosine residue Y1139 of ERBB2 in complex with ERBB4.
Literature References
PubMed ID
Title
Journal
Year
8622888
Signal transduction pathways induced by heregulin in MDA-MB-453 breast cancer cells
Cho, C
,
Sepp-Lorenzino, L
,
Lupu, R
,
Eberhard, I
,
Ma, Z
,
Serve, H
,
Liu, F
,
Rosen, N
Oncogene
1996
Participants
Input
GRB2-1:SOS1 [cytosol]
(Homo sapiens)
Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane]
(Homo sapiens)
Output
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
GRB2 events in ERBB2 signaling (Homo sapiens)
Orthologous Events
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Bos taurus)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Canis familiaris)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Danio rerio)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Drosophila melanogaster)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Gallus gallus)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Mus musculus)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Rattus norvegicus)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Sus scrofa)
Authored
Orlic-Milacic, M (2011-11-04)
Reviewed
Neckers, LM (2011-11-11)
Xu, W (2011-11-11)
Created
Orlic-Milacic, M (2011-05-28)
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