Regulatory subunit p85 of PI3K (PIK3R1) binds GAB1 in complex with GRB2 and phosphorylated ERBB2:EGFR heterodimer. Catalytic subunit p110 of PI3K (PIK3CA) is constitutively associated with the PIK3R1. Binding of PIK3R1 to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR triggers a conformational change in the PI3K complex, resulting in PI3K activation (Jackson et al. 2004).
Sliwkowski, MX, Brattain, MG, St Clair, P, Jackson, JG
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