Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR

Stable Identifier
R-HSA-1306965
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
ReviewStatus
5/5
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Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
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Regulatory subunit p85 of PI3K (PIK3R1) binds GAB1 in complex with GRB2 and phosphorylated ERBB2:EGFR heterodimer. Catalytic subunit p110 of PI3K (PIK3CA) is constitutively associated with the PIK3R1. Binding of PIK3R1 to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR triggers a conformational change in the PI3K complex, resulting in PI3K activation (Jackson et al. 2004).
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Orthologous Events
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Bos taurus)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Canis familiaris)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Gallus gallus)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Mus musculus)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Rattus norvegicus)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Sus scrofa)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-05-28)
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