Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.

Stable Identifier
R-HSA-1306965
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Regulatory subunit p85 of PI3K (PIK3R1) binds GAB1 in complex with GRB2 and phosphorylated ERBB2:EGFR heterodimer. Catalytic subunit p110 of PI3K (PIK3CA) is constitutively associated with the PIK3R1. Binding of PIK3R1 to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR triggers a conformational change in the PI3K complex, resulting in PI3K activation (Jackson et al. 2004).

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