Binding of GRB2:GAB1 to p-ERBB2:p-EGFR

Stable Identifier
R-HSA-1306963
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
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GAB1 in complex with GRB2 is recruited to activated ERBB2:EGFR heterodimer through phosphorylated tyrosine residues that serve as docking sites for GRB2 (Jackson et al. 2004).

Literature References
Participants
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Output
Participates
as an event of
Orthologous Events
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Canis familiaris)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Danio rerio)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Gallus gallus)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Mus musculus)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Rattus norvegicus)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Sus scrofa)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-05-28)
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