Binding of GRB2:GAB1 to p-ERBB2:p-EGFR

Stable Identifier
R-HSA-1306963
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
GAB1 in complex with GRB2 is recruited to activated ERBB2:EGFR heterodimer through phosphorylated tyrosine residues that serve as docking sites for GRB2 (Jackson et al. 2004).
Literature References
Participants
Input
Output
Participates
as an event of
Orthologous Events
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Canis familiaris)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Drosophila melanogaster)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Gallus gallus)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Mus musculus)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Rattus norvegicus)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Sus scrofa)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-05-28)
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