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Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
Stable Identifier
R-HSA-1306963
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
PI3K events in ERBB2 signaling (Homo sapiens)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
GAB1 in complex with GRB2 is recruited to activated ERBB2:EGFR heterodimer through phosphorylated tyrosine residues that serve as docking sites for GRB2 (Jackson et al. 2004).
Literature References
PubMed ID
Title
Journal
Year
15059917
Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects
Sliwkowski, MX
,
Brattain, MG
,
St Clair, P
,
Jackson, JG
Cancer Res
2004
Participants
Input
GRB2:GAB1 [cytosol]
(Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]
(Homo sapiens)
Output
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
PI3K events in ERBB2 signaling (Homo sapiens)
Orthologous Events
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Canis familiaris)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Drosophila melanogaster)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Gallus gallus)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Mus musculus)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Rattus norvegicus)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Sus scrofa)
Authored
Orlic-Milacic, M (2011-11-04)
Reviewed
Neckers, LM (2011-11-11)
Xu, W (2011-11-11)
Created
Orlic-Milacic, M (2011-05-28)
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