PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR

Stable Identifier
R-HSA-1306957
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Active PI3K in complex with p-EGFR:p-ERBB2:GRB2:GAB1 phosphorylates PIP2 into PIP3, leading to activation of AKT signaling (Jackson et al. 2004).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created