Active PI3K in complex with p-EGFR:p-ERBB2:GRB2:GAB1 phosphorylates PIP2 into PIP3, leading to activation of AKT signaling (Jackson et al. 2004).
Sliwkowski, MX, Brattain, MG, St Clair, P, Jackson, JG
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane]
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