Reactome | PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR

PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR

Stable Identifier

R-HSA-1306957

Type

Reaction

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

Locations in the PathwayBrowser

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PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR

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Active PI3K in complex with p-EGFR:p-ERBB2:GRB2:GAB1 phosphorylates PIP2 into PIP3, leading to activation of AKT signaling (Jackson et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15059917	Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects Sliwkowski, MX, Brattain, MG, St Clair, P, Jackson, JG	Cancer Res	2004

Participants

Input

Output

Participates

as an event of

PI3K events in ERBB2 signaling (Homo sapiens)

Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity of EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane]

Physical Entity

EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)

Activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)

Orthologous Events

PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)

PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Danio rerio)

PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Gallus gallus)

PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Mus musculus)

PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Rattus norvegicus)

PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Sus scrofa)

PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Xenopus tropicalis)

Cross References

Rhea

21292

Authored

Orlic-Milacic, M (2011-11-04)

Reviewed

Neckers, LM (2011-11-11)

Xu, W (2011-11-11)

Created

Orlic-Milacic, M (2011-05-27)

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