GRB7 events in ERBB2 signaling

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Homo sapiens
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Heterodimers of ERBB2 and ERBB3 are able to bind GRB7 (Fiddes et al. 1998) through phosphorylated tyrosine residues in the C-tail of ERBB3 (Y1199 and Y1262) (Fiddes et al. 1998), but the exact downstream signaling of this complex has not been elucidated. GRB7 can recruit SHC1 to the active ERBB2 complex, and contributes to ERBB2 signaling-induced RAS activation, which promotes cellular proliferation, but the exact mechanism has not been elucidated (Pradip et al. 2013). In addition, GRB7 can be phosphorylated by the integrin-activated PTK2 (FAK), leading to VAV2-dependent activation of RAC1 and promotion of cell migration. The exact mechanistic details of GRB7-induced RAC1 activation are not known (Pradip et al. 2013).

Literature References
PubMed ID Title Journal Year
23593540 Dissecting GRB7-mediated signals for proliferation and migration in HER2 overexpressing breast tumor cells: GTP-ase rules

Leyland-Jones, B, Bouzyk, M, Dey, N, Pradip, D

Am J Cancer Res 2013
9516479 Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3

Daly, RJ, Campbell, DH, Wallasch, C, Sasaki, H, Janes, PW, Fiddes, RJ, Sivertsen, SP

J Biol Chem 1998
Cross References
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