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Acrosome Reaction and Sperm:Oocyte Membrane Binding
Stable Identifier
R-HSA-1300645
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Reproduction (Homo sapiens)
Fertilization (Homo sapiens)
Acrosome Reaction and Sperm:Oocyte Membrane Binding (Homo sapiens)
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The acrosome reaction is stimulated by zona pellucida binding and subsequent downstream events, including Ca2+ influx. Proacrosin cleavage is the hallmark event of the acrosome reaction. After the acrosome reactome the sperm has passed through the cumulus cells and the zona pellucida. The membrane of the sperm head and the membrane of the oocyte are drawn together through the interaction of the sperm-bound protein Izumo and the ooctye CD9 membrane protein.
Literature References
PubMed ID
Title
Journal
Year
20364096
Fertilization: a sperm's journey to and interaction with the oocyte
Ikawa, M
,
Okabe, M
,
Inoue, N
,
Benham, AM
J Clin Invest
2010
Participants
Events
Acrosin Cleavage
(Homo sapiens)
Association of Acrosin Heavy and Light Chain
(Homo sapiens)
CD9:Izumo Binding
(Homo sapiens)
Participates
as an event of
Fertilization (Homo sapiens)
Event Information
Go Biological Process
acrosome reaction (0007340)
Orthologous Events
Acrosome Reaction and Sperm:Oocyte Membrane Binding (Bos taurus)
Acrosome Reaction and Sperm:Oocyte Membrane Binding (Canis familiaris)
Acrosome Reaction and Sperm:Oocyte Membrane Binding (Gallus gallus)
Acrosome Reaction and Sperm:Oocyte Membrane Binding (Mus musculus)
Acrosome Reaction and Sperm:Oocyte Membrane Binding (Rattus norvegicus)
Acrosome Reaction and Sperm:Oocyte Membrane Binding (Sus scrofa)
Acrosome Reaction and Sperm:Oocyte Membrane Binding (Xenopus tropicalis)
Authored
Gillespie, ME (2013-02-13)
Reviewed
Lishko, PV (2013-05-21)
Created
Gillespie, ME (2011-05-23)
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