TIMM9:TIMM10 binds hydrophobic proteins

Stable Identifier
R-HSA-1299481
Type
Reaction [binding]
Species
Homo sapiens
Compartment
mitochondrial intermembrane space, mitochondrial inner membrane
ReviewStatus
5/5
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TIMM9:TIMM10 binds hydrophobic proteins
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As inferred from the yeast TIM9:TIM10 complex, the human TIMM9:TIMM10:FXC1 complex chaperones hydrophobic membrane proteins in the intermembrane space until their insertion into the inner or outer membrane. Whereas the yeast TIM9:TIM10 complex is soluble in the intermembrane space, the human TIMM9:TIMM10 complex is associated with the outer surface of the inner membrane (Muhlebein et al. 2004).
Experimentally verified substrates of the yeast TIM9:TIM10 complex include AAC (ADP/ATP translocase 1, ANT, SLC25A4 in human), TIM17 (TIMM17 in human), TOM40 (TOMM40 in human), TIM23 (TIMM23 in human), TIM22 (TIMM22 in human), and Tafazzin (Tafazzin, TAZ in human). Many other mitochondrial proteins are anticipated to be chaperoned by the TIMM9:TIMM10 complex.
Literature References
PubMed ID Title Journal Year
19453276 Multiple pathways for mitochondrial protein traffic

Yamano, K, Endo, T

Biol Chem 2009
18174896 Multiple pathways for sorting mitochondrial precursor proteins

Pfanner, N, Wagner, R, Sickmann, A, Bolender, N, Meisinger, C

EMBO Rep 2008
14726512 Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria

Hofmann, S, Rothbauer, U, Mühlenbein, N, Bauer, MF

J Biol Chem 2004
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Output
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Inferred From
TIM9:TIM10 binds hydrophobic proteins (Saccharomyces cerevisiae)
Authored
May, B  (2011-05-21)
Reviewed
Endo, T  (2012-02-12)
D'Eustachio, P  (2011-11-02)
Created
May, B  (2011-05-23)
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