As inferred from yeast, the alpha subunit of the mitochondrial processing peptidase (MPP) binds presequences of mitochondrial precursors and the beta subunit cleaves the presequence. After cleavage, proteins destined for the matrix are drawn into the matrix by ATP-dependent interaction with mtHSP70 (HSPA9, homolog of yeast SSC1) of the PAM complex.
Yamano, K, Endo, T
Pfanner, N, Wagner, R, Sickmann, A, Bolender, N, Meisinger, C
metalloendopeptidase activity of Mitochondrial processing peptidase [mitochondrial inner membrane]
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