MPP cleaves targeting peptide (presequence) of matrix precursors

Stable Identifier
R-HSA-1299478
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix, mitochondrial inner membrane
ReviewStatus
5/5
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MPP cleaves targeting peptide (presequence) of matrix precursors
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As inferred from yeast, the alpha subunit of the mitochondrial processing peptidase (MPP) binds presequences of mitochondrial precursors and the beta subunit cleaves the presequence. After cleavage, proteins destined for the matrix are drawn into the matrix by ATP-dependent interaction with mtHSP70 (HSPA9, homolog of yeast SSC1) of the PAM complex.
Literature References
PubMed ID Title Journal Year
19453276 Multiple pathways for mitochondrial protein traffic

Endo, T, Yamano, K

Biol Chem 2009
18174896 Multiple pathways for sorting mitochondrial precursor proteins

Bolender, N, Sickmann, A, Wagner, R, Meisinger, C, Pfanner, N

EMBO Rep 2008
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Catalyst Activity

metalloendopeptidase activity of Mitochondrial processing peptidase [mitochondrial matrix]

Physical Entity
Mitochondrial processing peptidase [mitochondrial matrix] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Inferred From
MPP hydrolyzes presequence of matrix precursors (Saccharomyces cerevisiae)
Authored
May, B  (2011-05-21)
Reviewed
D'Eustachio, P  (2011-11-02)
Endo, T  (2012-02-12)
Created
May, B  (2011-05-23)
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