Reactome | PMPCA [mitochondrial matrix]

PMPCA [mitochondrial matrix]

Stable Identifier

R-HSA-1299450

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Mitochondrial-processing peptidase subunit alpha, MPPA_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q10713 PMPCA

Gene Names

PMPCA, INPP5E, KIAA0123, MPPA

Chain

transit peptide:1-33, chain:34-525

Reference Genes

BioGPS Gene:23203 PMPCA

COSMIC (genes):INPP5E PMPCA

COSMIC (genes):PMPCA PMPCA

CTD Gene:23203 PMPCA

dbSNP Gene:23203 PMPCA

ENSEMBL:ENSG00000165688 PMPCA

HGNC:18667 PMPCA

KEGG:hsa:23203 PMPCA

Monarch:23203 PMPCA

NCBI Gene:23203 PMPCA

OMIM:613036 PMPCA

UCSC:Q10713 PMPCA

Reference Transcript

Other Identifiers

11748770_a_at

11760871_x_at

17091239

212088_PM_at

212088_at

23203

2778014

3194339

3194340

3194341

3194342

3194343

3194344

3194345

3194346

3194347

3194348

3194350

3194351

3194352

3194353

3194354

3194355

3194356

3194357

3194358

3194359

3194360

3194361

3194362

3194363

3194364

3194365

3194366

3194367

3194368

3194369

3194370

3194371

3194372

3194374

36602_at

8159337

A_14_P126408

A_14_P135556

A_23_P32125

A_33_P3287537

D50913_at

GE80602

GO:0003824

GO:0004222

GO:0005515

GO:0005615

GO:0005739

GO:0005743

GO:0005759

GO:0006508

GO:0006627

GO:0016787

GO:0017087

GO:0043226

GO:0046872

GO:0051604

GO:0140096

HMNXSV003006688

HMNXSV003013782

Hs.75353.0.A1_3p_at

ILMN_1764239

PH_hs_0004318

PH_hs_0040204

TC09000812.hg

Participates

as a member of

Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)

as a component of

Mitochondrial processing peptidase [mitochondrial matrix] (Homo sapiens)

Inferred To

Dmel\CG8728 [mitochondrial matrix] (Drosophila melanogaster)

Pmpca [mitochondrial matrix] (Mus musculus)

Pmpca [mitochondrial matrix] (Rattus norvegicus)

mas2 [mitochondrial matrix] (Schizosaccharomyces pombe)

mppa-1 [mitochondrial matrix] (Caenorhabditis elegans)

PMPCA [mitochondrial matrix] (Bos taurus)

PMPCA [mitochondrial matrix] (Canis familiaris)

PMPCA [mitochondrial matrix] (Gallus gallus)

PMPCA [mitochondrial matrix] (Sus scrofa)

mppA1 [mitochondrial matrix] (Dictyostelium discoideum)

MAS2 [mitochondrial matrix] (Saccharomyces cerevisiae)

Cross References

ENSEMBL

ENSP00000516357, ENST00000706375, ENSP00000516285, ENST00000706228, ENST00000706227, ENSP00000516286, ENST00000371717, ENSP00000360782

OpenTargets

ENSG00000165688

HPA

ENSG00000165688-PMPCA

PRO

Q10713

Pharos - Targets

Q10713

GlyGen

Q10713

Orphanet

PMPCA

HMDB Protein

HMDBP02210

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HC36 MRM3	1	RNMTL1 [mitochondrial matrix] (R-HSA-6793067)	0.527	2
UniProt:Q80H93 8b	1	8b [cytosol] (R-COV-9678168)	0.527	2
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.527	2
UniProt:P01160 NPPA	5	NPPA(124-151) [extracellular region] (R-HSA-5578799) NPPA(1-151) [extracellular region] (R-HSA-976950) NPPA(1-25) [extracellular region] (R-HSA-5578791) NPPA(56-123) [extracellular region] (R-HSA-5578797) NPPA(26-55) [extracellular region] (R-HSA-5578794)	0.527	2

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