Reactome | PMPCA [mitochondrial inner membrane]

PMPCA [mitochondrial inner membrane]

Stable Identifier

R-HSA-1299450

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Mitochondrial-processing peptidase subunit alpha, MPPA_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q10713 PMPCA

Gene Names

PMPCA, INPP5E, KIAA0123, MPPA

Chain

transit peptide:1-33, chain:34-525

Reference Genes

BioGPS Gene:23203 PMPCA

COSMIC (genes):PMPCA PMPCA

CTD Gene:23203 PMPCA

dbSNP Gene:23203 PMPCA

ENSEMBL:ENSG00000165688 PMPCA

HGNC:18667 PMPCA

KEGG Gene (Homo sapiens):23203 PMPCA

Monarch:23203 PMPCA

NCBI Gene:23203 PMPCA

OMIM:613036 PMPCA

UCSC:Q10713 PMPCA

Reference Transcript

Other Identifiers

0005550091

11748770_a_at

17091239

212088_at

23203

2778014

3194339

3194340

3194342

3194344

3194347

3194351

3194355

3194356

3194357

3194358

3194359

3194360

3194363

3194371

3194372

36602_at

8159337

A_23_P32125

D50913_at

GE80602

GO:0003674

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005739

GO:0005743

GO:0005759

GO:0006508

GO:0006605

GO:0006627

GO:0006810

GO:0006851

GO:0007005

GO:0008150

GO:0015031

GO:0016020

GO:0043167

GO:0043226

GO:0046872

GO:0051604

GO:0055085

HMNXSV003013782

Hs.75353.0.A1_3p_at

ILMN_1764239

PH_hs_0004318

TC09000812.hg

Participates

as a component of

Mitochondrial processing peptidase [mitochondrial inner membrane] (Homo sapiens)

Inferred To

pmpca [mitochondrial inner membrane] (Danio rerio)

Dmel\CG8728 [mitochondrial inner membrane] (Drosophila melanogaster)

mppa-1 [mitochondrial inner membrane] (Caenorhabditis elegans)

PMPCA [mitochondrial inner membrane] (Canis familiaris)

PMPCA [mitochondrial inner membrane] (Gallus gallus)

PMPCA [mitochondrial inner membrane] (Sus scrofa)

Pmpca [mitochondrial inner membrane] (Mus musculus)

Pmpca [mitochondrial inner membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001269873.1, NP_055975.1, NP_001269875.1

OpenTargets

ENSG00000165688

HPA

ENSG00000165688-PMPCA

GeneCards

Q10713

Ensembl

ENST00000399219, ENST00000371717, ENSP00000416702, ENSP00000360782, ENSG00000165688

PRO

Q10713

Pharos - Targets

Q10713

Orphanet

23282

GlyGen

Q10713

HMDB Protein

HMDBP02210

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q80H93 8b	1	8b [cytosol] (R-COV-9678168)	0.527	2
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.527	2

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