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Activation of TALK
Stable Identifier
R-HSA-1299359
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Neuronal System (Homo sapiens)
Potassium Channels (Homo sapiens)
Tandem pore domain potassium channels (Homo sapiens)
TWIK-related alkaline pH activated K+ channel (TALK) (Homo sapiens)
Activation of TALK (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TALK is activated by increase in pH alkalinity in the extracellular fluid. Potassium is pumped out into the extracellular fluid.
Literature References
PubMed ID
Title
Journal
Year
12724142
Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1
Han, J
,
Kang, D
,
Kim, D
Am J Physiol Cell Physiol
2003
Participants
Input
K+ [cytosol]
Output
K+ [extracellular region]
Participates
as an event of
TWIK-related alkaline pH activated K+ channel (TALK) (Homo sapiens)
Catalyst Activity
potassium channel activity of TALK 1and 2 [plasma membrane]
Physical Entity
TALK 1and 2 [plasma membrane]
(Homo sapiens)
Activity
potassium channel activity (GO:0005267)
Orthologous Events
Activation of TALK (Bos taurus)
Activation of TALK (Canis familiaris)
Activation of TALK (Gallus gallus)
Activation of TALK (Mus musculus)
Activation of TALK (Rattus norvegicus)
Activation of TALK (Saccharomyces cerevisiae)
Activation of TALK (Sus scrofa)
Activation of TALK (Xenopus tropicalis)
Cross References
Rhea
29463
Authored
Mahajan, SS (2011-05-22)
Reviewed
Jassal, B (2010-09-23)
Created
Mahajan, SS (2011-05-23)
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