Activation of TRESK

Stable Identifier
R-HSA-1299338
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Activation of TRESK
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TRESK is expressed in spinal cord and brain and is involved in K+ efflux. TRESK activation may be mediated by calcineurin.
Literature References
PubMed ID Title Journal Year
20871611 A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura

Cader, MZ, Dubé, MP, Griffiths, LR, Marcinkiewicz, MM, Tucker, SJ, Andres-Enguix, I, Ramagopalan, S, Simoneau, M, Ansorge, O, Sequeiros, J, Lafrenière, F, Rouleau, GA, Boisvert, K, Lafrenière, RG, Gupta, N, Poulin, JF, Brais, B, Ebers, G, Pereira-Monteiro, JM, McLaughlan, S

Nat Med 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

potassium channel activity of TRESK homodimer [plasma membrane]

Physical Entity
TRESK homodimer [plasma membrane] (Homo sapiens)
Activity
potassium channel activity (GO:0005267)
Orthologous Events
Activation of TRESK (Bos taurus)
Activation of TRESK (Caenorhabditis elegans)
Activation of TRESK (Canis familiaris)
Activation of TRESK (Danio rerio)
Activation of TRESK (Drosophila melanogaster)
Activation of TRESK (Gallus gallus)
Activation of TRESK (Mus musculus)
Activation of TRESK (Rattus norvegicus)
Activation of TRESK (Saccharomyces cerevisiae)
Activation of TRESK (Xenopus tropicalis)
Cross References
Rhea
Authored
Mahajan, SS  (2011-05-22)
Reviewed
Jassal, B  (2010-09-23)
Created
Mahajan, SS  (2011-05-23)
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