Activation of THIK

Stable Identifier
R-HSA-1299297
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Activation of THIK
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THIK subfamily has 2 members, THIK1 and THIK 2. THIK 1 forms functional homodimers whereas THIK2 function has not been demonstrated. THIK1 channels are inhibited by halothane. THICK1 channels form K+ leak channels and are not regulated by acidity or alkalanity changes.

Literature References
PubMed ID Title Journal Year
18209473 Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney

Derst, C, Bachmann, S, Hirsch, JR, Theilig, F, Goranova, I, Veh, RW, Unsal, S, Wieske, M

Cell Physiol Biochem 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

potassium channel activity of THIK1 homodimers [plasma membrane]

Physical Entity
THIK1 homodimers [plasma membrane] (Homo sapiens)
Activity
potassium channel activity (GO:0005267)
Orthologous Events
Activation of THIK (Bos taurus)
Activation of THIK (Caenorhabditis elegans)
Activation of THIK (Canis familiaris)
Activation of THIK (Danio rerio)
Activation of THIK (Gallus gallus)
Activation of THIK (Mus musculus)
Activation of THIK (Rattus norvegicus)
Activation of THIK (Saccharomyces cerevisiae)
Activation of THIK (Sus scrofa)
Cross References
Rhea
Authored
Mahajan, SS  (2011-05-23)
Reviewed
Jassal, B  (2010-09-23)
Created
Mahajan, SS  (2011-05-23)
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