THIK subfamily has 2 members, THIK1 and THIK 2. THIK 1 forms functional homodimers whereas THIK2 function has not been demonstrated. THIK1 channels are inhibited by halothane. THICK1 channels form K+ leak channels and are not regulated by acidity or alkalanity changes.
Derst, C, Bachmann, S, Hirsch, JR, Theilig, F, Goranova, I, Veh, RW, Unsal, S, Wieske, M
potassium channel activity of THIK1 homodimers [plasma membrane]
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