Activation of THIK

Stable Identifier
R-HSA-1299297
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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THIK subfamily has 2 members, THIK1 and THIK 2. THIK 1 forms functional homodimers whereas THIK2 function has not been demonstrated. THIK1 channels are inhibited by halothane. THICK1 channels form K+ leak channels and are not regulated by acidity or alkalanity changes.

Literature References
PubMed ID Title Journal Year
18209473 Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney

Theilig, F, Goranova, I, Hirsch, JR, Wieske, M, Unsal, S, Bachmann, S, Veh, RW, Derst, C

Cell Physiol Biochem 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
potassium channel activity of THIK1 homodimers [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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