Acrosin Cleavage

Stable Identifier
R-HSA-1297354
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Acrosin is localized in the acrosomal matrix as an enzymatically inactive zymogen, proacrosin. Upon stimulation by zona pellucida binding and ca2+ influx, proacrosin is cleaved into a heavy and light chain.

Literature References
PubMed ID Title Journal Year
11080640 Effector sites in the three-dimensional structure of mammalian sperm beta-acrosin

Tranter, R, Read, JA, Jones, R, Brady, RL

Structure 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protease binding activity of ACR(20-421) [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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