Acrosin Cleavage

Stable Identifier
R-HSA-1297354
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
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Acrosin is localized in the acrosomal matrix as an enzymatically inactive zymogen, proacrosin. Upon stimulation by zona pellucida binding and ca2+ influx, proacrosin is cleaved into a heavy and light chain.
Literature References
PubMed ID Title Journal Year
11080640 Effector sites in the three-dimensional structure of mammalian sperm beta-acrosin

Brady, RL, Tranter, R, Read, JA, Jones, R

Structure 2000
Participants
Participates
Catalyst Activity

protease binding activity of ACR(20-421) [extracellular region]

Orthologous Events
Authored
Reviewed
Created
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