Acrosin Cleavage

Stable Identifier
R-HSA-1297354
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Acrosin Cleavage
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Acrosin is localized in the acrosomal matrix as an enzymatically inactive zymogen, proacrosin. Upon stimulation by zona pellucida binding and ca2+ influx, proacrosin is cleaved into a heavy and light chain.
Literature References
PubMed ID Title Journal Year
11080640 Effector sites in the three-dimensional structure of mammalian sperm beta-acrosin

Brady, RL, Tranter, R, Read, JA, Jones, R

Structure 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protease binding activity of ACR(20-421) [extracellular region]

Physical Entity
ACR(20-421) [extracellular region] (Homo sapiens)
Activity
protease binding (GO:0002020)
Orthologous Events
Acrosin Cleavage (Bos taurus)
Acrosin Cleavage (Canis familiaris)
Acrosin Cleavage (Gallus gallus)
Acrosin Cleavage (Mus musculus)
Acrosin Cleavage (Rattus norvegicus)
Acrosin Cleavage (Sus scrofa)
Acrosin Cleavage (Xenopus tropicalis)
Authored
Gillespie, ME  (2013-02-13)
Reviewed
Lishko, PV  (2013-05-21)
Created
Gillespie, ME  (2011-05-21)
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