NLRP3 oligomerizes via NACHT domains

Stable Identifier
R-HSA-1296421
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Staphylococcus aureus
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NLRP3 oligomerizes via NACHT domains
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
NLRP3 contains a NACHT/NOD domain that in related proteins is responsible for oligomerization (Inohara & Nunez 2001, 2003). NLRP1 forms oligomers upon stimulation with MDP (Faustin et al. 2007) and the enforced oligomerization of NLRP3 PYD domains enhances ASC-dependent effects on apoptosis (Dowds et al. 2002). NOD-mediated oligomerization is widely considered to be part of the activation process for the NLRP3 inflammasome (Schroder et al. 2010, Schroder & Tschopp, 2010). The extent of oligomerization is not known, but models based on the the apoptotic initiator protein Apaf-1 suggest a posible heptameric platform (Proell et al. 2008).
Literature References
PubMed ID Title Journal Year
17703304 NALP inflammasomes: a central role in innate immunity

Mayor, A, Pétrilli, V, Gaide, O, Martinon, F, Tschopp, J

Semin Immunopathol 2007
17349957 Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation

Lartigue, L, Reed, JC, Rouiller, I, Bruey, JM, Faustin, B, Sergienko, E, Volkmann, N, Luciano, F, Bailly-Maitre, B, Hanein, D

Mol Cell 2007
Participants
Input
Output
Participates
as an event of
Authored
Jupe, S  (2010-04-22)
Reviewed
Kufer, TA  (2011-04-28)
Rittinger, K  (2011-06-06)
Wong, E  (2011-06-06)
Created
Jupe, S  (2011-05-20)
Cite Us!