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KCNK2 [plasma membrane]
Stable Identifier
R-HSA-1296328
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Potassium channel subfamily K member 2 (TREK1), KCNK2_HUMAN
Locations in the PathwayBrowser
Expand all
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Phase 4 - resting membrane potential (Homo sapiens)
KCNK dimers transport K+ from cytosol to extracellular region (Homo sapiens)
KCNK dimers [plasma membrane] (Homo sapiens)
KCNK2 dimer [plasma membrane] (Homo sapiens)
KCNK2 [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Potassium Channels (Homo sapiens)
Tandem pore domain potassium channels (Homo sapiens)
TWIK related potassium channel (TREK) (Homo sapiens)
Activation of TWIK-related K+ channel (TREK) (Homo sapiens)
TREK homodimers [plasma membrane] (Homo sapiens)
TREK members [plasma membrane] (Homo sapiens)
KCNK2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95069 KCNK2
Gene Names
KCNK2, TREK, TREK1
Chain
chain:1-426
Reference Genes
BioGPS Gene:3776 KCNK2
COSMIC (genes):KCNK2 KCNK2
CTD Gene:3776 KCNK2
dbSNP Gene:3776 KCNK2
ENSEMBL:ENSG00000082482 KCNK2
HGNC:6277 KCNK2
KEGG:hsa:3776 KCNK2
Monarch:3776 KCNK2
NCBI Gene:3776 KCNK2
OMIM:603219 KCNK2
UCSC:O95069 KCNK2
Reference Transcript
RefSeq:NM_001017425.2 KCNK2
RefSeq:NM_001017424.2 KCNK2
RefSeq:NM_014217.3 KCNK2
RefSeq:XM_017001248.1 KCNK2
Other Identifiers
11730493_a_at
11730494_x_at
11741048_a_at
11751700_a_at
11756844_a_at
16677451
210261_PM_at
210261_at
2379978
2379979
2379980
2379984
2379985
2379986
2379987
2379988
2379989
2379990
2379991
2379996
2380001
2380006
2380007
2380010
2380014
2380015
2380016
2380017
2380018
2380019
2380020
34087_at
3776
7909730
A_14_P136977
A_23_P43713
A_33_P3213822
GE81899
GO:0003231
GO:0005215
GO:0005249
GO:0005267
GO:0005783
GO:0005789
GO:0005886
GO:0006813
GO:0007186
GO:0007613
GO:0008076
GO:0009612
GO:0009986
GO:0014047
GO:0015271
GO:0016020
GO:0016324
GO:0019228
GO:0019870
GO:0022834
GO:0022841
GO:0030322
GO:0030424
GO:0030425
GO:0032228
GO:0033268
GO:0034220
GO:0042391
GO:0042802
GO:0043025
GO:0043226
GO:0043679
GO:0044305
GO:0046982
GO:0048678
GO:0048856
GO:0050877
GO:0050976
GO:0055085
GO:0060044
GO:0071456
GO:0071805
GO:0090102
GO:0097449
GO:0098685
GO:0098772
GO:0098782
GO:0099565
GO:1900039
GO:1902476
GO:1904551
GO:2000279
HMNXSV003004706
HMNXSV003036368
HMNXSV003056316
ILMN_1666656
ILMN_1765990
ILMN_2277334
ILMN_2376953
PH_hs_0011941
PH_hs_0034127
TC01001792.hg
g4101565_3p_at
Participates
as a member of
TREK members [plasma membrane] (Homo sapiens)
as a component of
KCNK2 dimer [plasma membrane] (Homo sapiens)
Inferred To
TOK1 [plasma membrane]
(Saccharomyces cerevisiae)
kcnk2 [plasma membrane]
(Xenopus tropicalis)
twk-8 [plasma membrane]
(Caenorhabditis elegans)
twk-1 [plasma membrane]
(Caenorhabditis elegans)
twk-33 [plasma membrane]
(Caenorhabditis elegans)
KCNK2 [plasma membrane]
(Bos taurus)
KCNK2 [plasma membrane]
(Caenorhabditis elegans)
KCNK2 [plasma membrane]
(Gallus gallus)
KCNK2 [plasma membrane]
(Mus musculus)
KCNK2 [plasma membrane]
(Rattus norvegicus)
KCNK2 [plasma membrane]
(Sus scrofa)
twk-36 [plasma membrane]
(Caenorhabditis elegans)
twk-18 [plasma membrane]
(Caenorhabditis elegans)
twk-42 [plasma membrane]
(Caenorhabditis elegans)
CG15655 [plasma membrane]
(Drosophila melanogaster)
twk-35 [plasma membrane]
(Caenorhabditis elegans)
twk-22 [plasma membrane]
(Caenorhabditis elegans)
kcnk2b [plasma membrane]
(Danio rerio)
twk-45 [plasma membrane]
(Caenorhabditis elegans)
twk-25 [plasma membrane]
(Caenorhabditis elegans)
twk-26 [plasma membrane]
(Caenorhabditis elegans)
twk-49 [plasma membrane]
(Caenorhabditis elegans)
Homologues of KCNK2 [plasma membrane]
(Caenorhabditis elegans)
twk-21 [plasma membrane]
(Caenorhabditis elegans)
twk-44 [plasma membrane]
(Caenorhabditis elegans)
twk-11 [plasma membrane]
(Caenorhabditis elegans)
twk-31 [plasma membrane]
(Caenorhabditis elegans)
twk-34 [plasma membrane]
(Caenorhabditis elegans)
twk-24 [plasma membrane]
(Caenorhabditis elegans)
Cross References
Guide to Pharmacology - Targets
514
ENSEMBL
ENSP00000394033
,
ENSP00000420203
,
ENST00000391895
,
ENST00000391894
,
ENSP00000375765
,
ENST00000467031
,
ENSP00000375764
,
ENST00000444842
,
ENSG00000082482
OpenTargets
ENSG00000082482
ZINC - FDA approved
KCNK2_HUMAN
ZINC - Substances
KCNK2_HUMAN
ZINC target
O95069
PRO
O95069
GlyGen
O95069
PDB
4TWK
GeneCards
KCNK2
HPA
ENSG00000082482-KCNK2
Pharos - Targets
O95069
ZINC - Predictions - Purchasable
KCNK2_HUMAN
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