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G protein gated Potassium channels
Stable Identifier
R-HSA-1296059
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Neuronal System (Homo sapiens)
Potassium Channels (Homo sapiens)
Inwardly rectifying K+ channels (Homo sapiens)
G protein gated Potassium channels (Homo sapiens)
General
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Inwardly rectifying G protein activated K+ channels (GIRK) are tetrameric assemblies of Ki3 3 family subunits (Kir 3.1, 3.2 3.3 and 3.4). The activation of G protein coupled receptor by ligand results in the liberation of G alpha and G beta gamma subunits. Gbeta gamma subunits interact and activate GIRK channels.
Literature References
PubMed ID
Title
Journal
Year
20921230
Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate
D'Avanzo, N
,
Cheng, WW
,
Nichols, CG
,
Doyle, DA
J Biol Chem
2010
Participants
Events
Activation of G protein gated Potassium channels
(Homo sapiens)
Participates
as an event of
Inwardly rectifying K+ channels (Homo sapiens)
Event Information
Go Biological Process
potassium ion transmembrane transport (0071805)
Orthologous Events
G protein gated Potassium channels (Bos taurus)
G protein gated Potassium channels (Caenorhabditis elegans)
G protein gated Potassium channels (Canis familiaris)
G protein gated Potassium channels (Drosophila melanogaster)
G protein gated Potassium channels (Gallus gallus)
G protein gated Potassium channels (Mus musculus)
G protein gated Potassium channels (Rattus norvegicus)
G protein gated Potassium channels (Sus scrofa)
G protein gated Potassium channels (Xenopus tropicalis)
Authored
Mahajan, SS (2011-05-19)
Reviewed
Jassal, B (2010-09-23)
Created
Mahajan, SS (2011-05-19)
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