G protein gated Potassium channels

Stable Identifier
R-HSA-1296059
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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G protein gated Potassium channels
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Inwardly rectifying G protein activated K+ channels (GIRK) are tetrameric assemblies of Ki3 3 family subunits (Kir 3.1, 3.2 3.3 and 3.4). The activation of G protein coupled receptor by ligand results in the liberation of G alpha and G beta gamma subunits. Gbeta gamma subunits interact and activate GIRK channels.
Literature References
PubMed ID Title Journal Year
20921230 Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate

D'Avanzo, N, Cheng, WW, Nichols, CG, Doyle, DA

J Biol Chem 2010
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Event Information
Go Biological Process
potassium ion transmembrane transport (0071805)
Orthologous Events
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G protein gated Potassium channels (Gallus gallus)
G protein gated Potassium channels (Mus musculus)
G protein gated Potassium channels (Rattus norvegicus)
G protein gated Potassium channels (Sus scrofa)
G protein gated Potassium channels (Xenopus tropicalis)
Authored
Mahajan, SS  (2011-05-19)
Reviewed
Jassal, B  (2010-09-23)
Created
Mahajan, SS  (2011-05-19)
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