Classical Kir channels

Stable Identifier
R-HSA-1296053
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
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Classical Kir channels
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Classical Kir channels are inwardly rectifying K+ channels with strong inwardly rectifying currents that contribute to highly negative resting membrane potential, prolonged action potential plateau and rapid repolarization in the final stage of action potential. Classical Kir channels are found in various cells such as cardiac myocytes, purkinje fibers, atrial and ventricular tissues. Rectification is caused by intracellular Mg2+ ions and polyamines.

Literature References
PubMed ID Title Journal Year
10599834 Inward rectifier potassium channel Kir 2.3 is inhibited by internal sulfhydryl modification

Conti, LR, Vandenberg, CA, Radeke, CM

Neuroreport 1999
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Events
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Event Information
Go Biological Process
potassium ion transmembrane transport (0071805)
Orthologous Events
Classical Kir channels (Bos taurus)
Classical Kir channels (Caenorhabditis elegans)
Classical Kir channels (Canis familiaris)
Classical Kir channels (Danio rerio)
Classical Kir channels (Drosophila melanogaster)
Classical Kir channels (Gallus gallus)
Classical Kir channels (Mus musculus)
Classical Kir channels (Rattus norvegicus)
Classical Kir channels (Sus scrofa)
Classical Kir channels (Xenopus tropicalis)
Authored
Mahajan, SS  (2011-05-18)
Reviewed
Jassal, B  (2010-09-23)
Created
Mahajan, SS  (2011-05-19)
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