Classical Kir channels

Stable Identifier
R-HSA-1296053
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Classical Kir channels
Click the image above or here to open this pathway in the Pathway Browser

Classical Kir channels are inwardly rectifying K+ channels with strong inwardly rectifying currents that contribute to highly negative resting membrane potential, prolonged action potential plateau and rapid repolarization in the final stage of action potential. Classical Kir channels are found in various cells such as cardiac myocytes, purkinje fibers, atrial and ventricular tissues. Rectification is caused by intracellular Mg2+ ions and polyamines.

Literature References
PubMed ID Title Journal Year
10599834 Inward rectifier potassium channel Kir 2.3 is inhibited by internal sulfhydryl modification

Radeke, CM, Conti, LR, Vandenberg, CA

Neuroreport 1999
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
potassium ion transmembrane transport (0071805)
Orthologous Events
Classical Kir channels (Bos taurus)
Classical Kir channels (Caenorhabditis elegans)
Classical Kir channels (Canis familiaris)
Classical Kir channels (Danio rerio)
Classical Kir channels (Drosophila melanogaster)
Classical Kir channels (Gallus gallus)
Classical Kir channels (Mus musculus)
Classical Kir channels (Rattus norvegicus)
Classical Kir channels (Sus scrofa)
Classical Kir channels (Xenopus tropicalis)
Authored
Mahajan, SS  (2011-05-18)
Reviewed
Jassal, B  (2010-09-23)
Created
Mahajan, SS  (2011-05-19)
Cite Us!