Reactome | KCNJ1 [plasma membrane]

KCNJ1 [plasma membrane]

Stable Identifier

R-HSA-1296028

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ATP-sensitive inward rectifier potassium channel (kir 1.1)1, IRK1_HUMAN, Kir 1.1

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Potassium Channels (Homo sapiens)
  - Inwardly rectifying K+ channels (Homo sapiens)
    - Potassium transport channels (Homo sapiens)
      - Activation of Potassium transport channels (Homo sapiens)
        
        Potassium transport channels (Kir 1.1 and Kir 4.1/5.1) [plasma membrane] (Homo sapiens)
        
        KIR 1.1 homotetramer [plasma membrane] (Homo sapiens)
        
        KCNJ1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48048 KCNJ1

Gene Names

KCNJ1, ROMK1

Chain

chain:1-391

Reference Genes

BioGPS Gene:3758 KCNJ1

COSMIC (genes):KCNJ1 KCNJ1

CTD Gene:3758 KCNJ1

dbSNP Gene:3758 KCNJ1

ENSEMBL:ENSG00000151704 KCNJ1

ENSEMBL_homo_sapiens_GENE:ENSG00000151704.16 KCNJ1

HGNC:6255 KCNJ1

KEGG Gene (Homo sapiens):3758 KCNJ1

Monarch:3758 KCNJ1

NCBI Gene:3758 KCNJ1

OMIM:600359 KCNJ1

UCSC:P48048 KCNJ1

Reference Transcript

Other Identifiers

11724453_a_at

11741318_a_at

11741364_a_at

16746027

210402_PM_at

210402_at

210403_PM_s_at

210403_s_at

3397771

3397773

3397775

3397776

3397777

3397778

3397781

3397782

3397787

3397789

3397790

3397791

36327_at

3758

7952617

A_23_P202918

A_23_P501781

A_33_P3252003

GE58870

GO:0000166

GO:0005215

GO:0005242

GO:0005524

GO:0005546

GO:0005886

GO:0006811

GO:0006813

GO:0008289

GO:0015272

GO:0016020

GO:0034220

GO:0034702

GO:0034765

GO:0055085

GO:1990573

HMNXSV003014839

ILMN_1749415

ILMN_2270802

ILMN_2357944

PH_hs_0000058

TC11002443.hg

TC11003408.hg

U65406_rna4_at

g433142_3p_at

g529316_3p_a_at

Participates

as a component of

KIR 1.1 homotetramer [plasma membrane] (Homo sapiens)

Inferred To

KCNJ1 [plasma membrane] (Bos taurus)

KCNJ1 [plasma membrane] (Canis familiaris)

KCNJ1 [plasma membrane] (Gallus gallus)

KCNJ1 [plasma membrane] (Mus musculus)

KCNJ1 [plasma membrane] (Rattus norvegicus)

KCNJ1 [plasma membrane] (Sus scrofa)

irk-2 [plasma membrane] (Caenorhabditis elegans)

Irk1 [plasma membrane] (Drosophila melanogaster)

irk-3 [plasma membrane] (Caenorhabditis elegans)

Irk3 [plasma membrane] (Drosophila melanogaster)

irk-1 [plasma membrane] (Caenorhabditis elegans)

Homologues of KCNJ1 [plasma membrane] (Caenorhabditis elegans)

Homologues of KCNJ1 [plasma membrane] (Drosophila melanogaster)

Irk2 [plasma membrane] (Drosophila melanogaster)

kcnj1 [plasma membrane] (Danio rerio)

kcnj1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_000211.1, NP_722448.1, NP_722450.1, NP_722449.3, NP_722451.1

Guide to Pharmacology - Targets

429

OpenTargets

ENSG00000151704

ZINC - Substances

KCNJ1_HUMAN

ZINC target

P48048

PRO

P48048

HPA

ENSG00000151704-KCNJ1

GeneCards

P48048

Ensembl

ENSP00000376432, ENST00000392665, ENST00000392664, ENSP00000376433, ENSP00000316233, ENSG00000151704, ENSP00000376434, ENSP00000406320, ENST00000324036, ENST00000392666, ENST00000440599

Pharos - Targets

P48048

Orphanet

16291

ZINC - Predictions - Purchasable

KCNJ1_HUMAN

HMDB Protein

HMDBP02585