Reactome | p-S111,S120-SPRY2 [cytosol]

p-S111,S120-SPRY2 [cytosol]

Stable Identifier

R-HSA-1295590

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

S111/S120 p-SPRY2

Locations in the PathwayBrowser for interactor UniProt:Q8NEC5 CATSPER1

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Literature References

PubMed ID	Title	Journal	Year
19690147	Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation Brady, SC, Coleman, ML, Olson, MF, Feller, SM, Munro, J, Morrice, NA	Cancer Res	2009

External Reference Information

External Reference

UniProt:O43597 SPRY2

Gene Names

SPRY2

Chain

chain:1-315

Reference Genes

BioGPS Gene:10253 SPRY2

COSMIC (genes):SPRY2 SPRY2

CTD Gene:10253 SPRY2

dbSNP Gene:10253 SPRY2

ENSEMBL:ENSG00000136158 SPRY2

ENSEMBL_homo_sapiens_GENE:ENSG00000136158.12 SPRY2

HGNC:11270 SPRY2

KEGG Gene (Homo sapiens):10253 SPRY2

Monarch:10253 SPRY2

NCBI Gene:10253 SPRY2

OMIM:602466 SPRY2

UCSC:O43597 SPRY2

Reference Transcript

Other Identifiers

10253

11753988_a_at

16780069

204011_PM_at

204011_at

33700_at

3519323

3519324

3519325

3519326

3519327

3519328

3519330

3519331

3519332

7972217

A_23_P128698

GE54345

GO:0000132

GO:0000278

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005874

GO:0005886

GO:0007010

GO:0007163

GO:0007275

GO:0007605

GO:0008285

GO:0008543

GO:0009966

GO:0010628

GO:0010719

GO:0010801

GO:0012501

GO:0015629

GO:0015630

GO:0016020

GO:0016525

GO:0019901

GO:0023052

GO:0030154

GO:0030291

GO:0030324

GO:0030335

GO:0030512

GO:0031345

GO:0031397

GO:0032587

GO:0033138

GO:0035924

GO:0036211

GO:0040037

GO:0042472

GO:0042995

GO:0043066

GO:0043226

GO:0043539

GO:0045165

GO:0045742

GO:0046580

GO:0048513

GO:0048754

GO:0048856

GO:0048870

GO:0050877

GO:0051387

GO:0051897

GO:0055105

GO:0060425

GO:0060437

GO:0060449

GO:0060541

GO:0070371

GO:0070373

GO:0070374

GO:0098772

GO:0140678

GO:1900747

GO:1902747

GO:1990752

GO:1990830

HMNXSV003025201

ILMN_2089329

PH_hs_0001652

TC13000763.hg

g5032114_3p_at

Participates

as an output of

B-RAF dissociates from S111/S120 p-SPRY2 (Homo sapiens)

as a component of

S111/S120 p-SPRY2:B-RAF [cytosol] (Homo sapiens)

Other forms of this molecule

p-Y55,Y227-SPRY2 [plasma membrane]

p-Y55-SPRY2 [cytosol]

SPRY2 [plasma membrane]

SPRY2 [cytosol]

p-S112,S115-SPRY2 [cytosol]

p-Y55,Y227-SPRY2 [plasma membrane]

p-S112,S121-SPRY2 [plasma membrane]

Inferred To

phospho-sty [cytosol] (Drosophila melanogaster)

phospho-Spry2 [cytosol] (Mus musculus)

phospho-Spry2 [cytosol] (Rattus norvegicus)

phospho-p-S111,S120-SPRY2 [cytosol] (Gallus gallus)

phospho-p-S111,S120-SPRY2 [cytosol] (Sus scrofa)

phospho-SPRY2 [cytosol] (Bos taurus)

phospho-SPRY2 [cytosol] (Canis familiaris)

Modified Residues

Name

O-phospho-L-serine at 111

Coordinate

111

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 120

Coordinate

120

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001305465.1, NP_001305466.1, NP_001305467.1, NP_005833.1

OpenTargets

ENSG00000136158

GeneCards

O43597

HPA

ENSG00000136158-SPRY2

Ensembl

ENST00000377104, ENSP00000366308, ENSP00000366306, ENST00000377102, ENSG00000136158

PRO

O43597

Pharos - Targets

O43597

PDB

3BUM, 5HL0, 3OB1, 5HKY, 5HKZ

Interactors (66)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.856	17
UniProt:Q5T7P3 LCE1B	1	LCE1B [cytosol] (R-HSA-6814271)	0.742	5
UniProt:P57075 UBS3A			0.666	4
UniProt:Q9BQ66 KR412			0.666	4
UniProt:O43741 PRKAB2	2	PRKAB2 [cytosol] (R-HSA-200413) PRKAB2 [nucleoplasm] (R-HSA-164096)	0.666	4
UniProt:Q8IUH5 ZDH17			0.666	4
UniProt:P32242 OTX1			0.666	4
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.591	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
UniProt:Q99750 MDFI			0.556	3
UniProt:Q5TA82 LCE2D	1	LCE2D [cytosol] (R-HSA-6814300)	0.556	3
UniProt:Q9NVQ4 FAIM1			0.556	3
UniProt:Q12527	3	ATG11 [cytosol] (R-SCE-5333627) phospho-ATG11 [cytosol] (R-SCE-5675845) ATG11 [endoplasmic reticulum membrane] (R-SCE-8948046)	0.556	3
UniProt:Q9BYR0 KRTAP4-7	1	KRTAP4-7 [cytosol] (R-HSA-6809963)	0.556	3
UniProt:Q6P2C6 Q6P2C6			0.556	3
UniProt:Q9UJV3-2 MID2			0.556	3
UniProt:P07510-2 CHRNG			0.556	3
UniProt:Q9H2X0 CHRD			0.556	3
UniProt:Q8NEC5 CATSPER1	1	CATSPER1 [plasma membrane] (R-HSA-2534335)	0.556	3
UniProt:Q5T5A8 LCE3C	1	LCE3C [cytosol] (R-HSA-6814279)	0.556	3
UniProt:Q86UY0 Q86UY0			0.556	3
IntAct:EBI-16428938 CCSB ISOFORM ID			0.556	3
UniProt:Q9NUL5 SHFL			0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:P14770 GP9	1	GP9 [plasma membrane] (R-HSA-55881)	0.556	3
UniProt:Q17RB8 LONRF1	1	LONRF1 [cytosol] (R-HSA-8850905)	0.556	3
UniProt:Q02930-3 CREB5			0.556	3
UniProt:P32502	1	GCD7 [cytosol] (R-SCE-72519)	0.556	3
UniProt:Q5JPT6 Q5JPT6			0.556	3
UniProt:Q06455-4 RUNX1T1			0.556	3
UniProt:Q8TF42 UBS3B			0.556	3
UniProt:Q5TA78 LCE4A	1	LCE4A [cytosol] (R-HSA-6814272)	0.556	3
UniProt:Q12259 YL108			0.556	3
UniProt:Q9UKS6 PACSIN3	1	PACSIN3 [cytosol] (R-HSA-8868270)	0.556	3
UniProt:Q96MH2 HEXI2			0.556	3
UniProt:O60336 MABP1			0.556	3
UniProt:P06782	5	PRKAA2 [nucleoplasm] (R-SCE-163682) PRKAA1 [cytosol] (R-SCE-380935) phospho-p-T183-PRKAA1 [cytosol] (R-SCE-380964) phospho-p-T172-PRKAA2 [cytosol] (R-SCE-200417) PRKAA2 [cytosol] (R-SCE-200405)	0.556	3
UniProt:Q9Y4C2 TCAF1			0.556	3
UniProt:Q14847 LASP1			0.556	3
UniProt:Q9Y2K6 USP20	1	USP20 [cytosol] (R-HSA-5696946)	0.556	3
UniProt:O75716 STK16			0.556	3
UniProt:O43559 FRS3	3	p-5Y-FRS3 [plasma membrane] (R-HSA-191475) FRS3 [plasma membrane] (R-HSA-191482) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.556	3
UniProt:P29972 AQP1	1	AQP1 [plasma membrane] (R-HSA-431700)	0.556	3
UniProt:Q9Y223 GNE	9	GNE V572L [cytosol] (R-HSA-4088323) GNE M712T [cytosol] (R-HSA-4088386) GNE R263L [cytosol] (R-HSA-4088402) GNE R266W [cytosol] (R-HSA-4088372) GNE R266Q [cytosol] (R-HSA-4088390) GNE A631V [cytosol] (R-HSA-4088376) GNE M171V [cytosol] (R-HSA-4088351) GNE C303V [cytosol] (R-HSA-4088366) GNE [cytosol] (R-HSA-3781927)	0.556	3
IntAct:EBI-10173330 386677			0.556	3
UniProt:O60573 EIF4E2	1	EIF4E2 [cytosol] (R-HSA-1678822)	0.556	3
UniProt:Q96SQ5 ZNF587	1	ZNF587 [nucleoplasm] (R-HSA-2127565)	0.556	3
UniProt:P60412 KRTAP10-11	1	KRTAP10-11 [cytosol] (R-HSA-6810243)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
UniProt:P43115-12 PTGER3			0.556	3
UniProt:Q6L8G9 KRTAP5-6	1	KRTAP5-6 [cytosol] (R-HSA-6810276)	0.556	3
UniProt:O43609 SPRY1	3	p-Y53-SPRY1 [cytosol] (R-HSA-182933) SPRY1 [plasma membrane] (R-HSA-182944) SPRY1 [cytosol] (R-HSA-182908)	0.556	3
UniProt:P60370 KRTAP10-5	1	KRTAP10-5 [cytosol] (R-HSA-6810260)	0.556	3
UniProt:Q9BYQ2 KRTAP9-4	1	KRTAP9-4 [cytosol] (R-HSA-6809971)	0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:Q5T5B0 LCE3E	1	LCE3E [cytosol] (R-HSA-6814280)	0.556	3
UniProt:Q9BYQ6 KRTAP4-11	1	KRTAP4-11 [cytosol] (R-HSA-6809960)	0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:Q9H2F3 HSD3B7	1	HSD3B7 [endoplasmic reticulum membrane] (R-HSA-193441)	0.556	3
UniProt:Q9BYQ4 KRTAP9-2	1	KRTAP9-2 [cytosol] (R-HSA-6809965)	0.556	3
UniProt:Q8TAU3 ZNF417	1	ZNF417 [nucleoplasm] (R-HSA-1247539)	0.556	3
UniProt:Q8WXE1 ATRIP	1	ATRIP [nucleoplasm] (R-HSA-176231)	0.556	3
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.556	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	3
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.499	2

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