Reactome | ERBB4jmAcyt1s80 [mitochondrial matrix]

ERBB4jmAcyt1s80 [mitochondrial matrix]

Stable Identifier

R-HSA-1254405

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

p-Y1056,Y1188,Y1242-ERBB4-1(676-1308)

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External Reference Information

External Reference

UniProt:Q15303-1 ERBB4

Gene Names

ERBB4, HER4

Participates

as a component of

ERBB4jmAcyt1s80 dimer [mitochondrial matrix] (Homo sapiens)

Other forms of this molecule

ERBB4jmAcyt1s80 [nucleoplasm]

ERBB4jmAcyt1ECD [extracellular region]

ERBB4jmAcyt1m80 [plasma membrane]

ERBB4jmAcyt1s80 [cytosol]

ERBB4 JM-A CYT-1 isoform [plasma membrane]

p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform [plasma membrane]

Inferred To

phospho-ERBB4 [mitochondrial matrix] (Canis familiaris)

phospho-ERBB4jmAcyt1s80 [mitochondrial matrix] (Bos taurus)

phospho-ERBB4jmAcyt1s80 [mitochondrial matrix] (Caenorhabditis elegans)

phospho-ERBB4jmAcyt1s80 [mitochondrial matrix] (Danio rerio)

phospho-ERBB4jmAcyt1s80 [mitochondrial matrix] (Drosophila melanogaster)

phospho-ERBB4jmAcyt1s80 [mitochondrial matrix] (Gallus gallus)

phospho-ERBB4jmAcyt1s80 [mitochondrial matrix] (Mus musculus)

phospho-ERBB4jmAcyt1s80 [mitochondrial matrix] (Rattus norvegicus)

phospho-ERBB4jmAcyt1s80 [mitochondrial matrix] (Sus scrofa)

phospho-ERBB4jmAcyt1s80 [mitochondrial matrix] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 1056

Coordinate

1056

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1188

Coordinate

1188

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1242

Coordinate

1242

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.816	5
UniProt:P78352 DLG4	3	DLG4 [plasma membrane] (R-HSA-202135) DLG4 [endocytic vesicle membrane] (R-HSA-416847) DLG4 [cytosol] (R-HSA-6794267)	0.646	6
UniProt:P29353 SHC1	5	p-Y-SHC1 [cytosol] (R-HSA-162568) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y427-SHC1 [cytosol] (R-HSA-74684)	0.609	6
UniProt:Q96JA1 LRIG1	2	Ub-LRIG1 [plasma membrane] (R-HSA-8875434) LRIG1 [plasma membrane] (R-HSA-197745)	0.589	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.577	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.573	7
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.573	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.564	3
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.553	2
UniProt:Q9UBN7 HDAC6	4	HDAC6 [lysosomal lumen] (R-HSA-9660002) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589)	0.553	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.524	2

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