Reactome | ERBB4jmAcyt2s80 [mitochondrial matrix]

ERBB4jmAcyt2s80 [mitochondrial matrix]

Stable Identifier

R-HSA-1254387

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

p-Y1172,Y1226-ERBB4-3(676-1292)

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External Reference Information

External Reference

UniProt:Q15303-3 ERBB4

Gene Names

ERBB4, HER4

Other Identifiers

0002120022

0100580450

11725911_a_at

11725912_a_at

11725913_a_at

12016

16907863

1727_at

2066

206794_at

214053_at

25522

2597563

2597564

2597565

2597566

2597567

2597568

2597569

2597570

2597571

2597580

2597581

2597583

2597584

2597586

2597609

2597615

2597616

2597617

2597621

2597626

2597628

2597629

2597631

2597632

2597633

2597635

2597636

2597637

2597638

2597646

2597661

2597684

2597720

2597788

2597789

276

2AHX

2L2T

2LCX

2R4B

37273_at

3BBT

3BBW

3BCE

3U2P

3U7U

3U9U

8058627

92081_at

A0A0A0MSE1

A_23_P423853

A_32_P183765

A_33_P3211558

AAB59446

AAI12200

AAI43742

AAI43748

AAI43750

AB209697

BAD92934

BC112199

BC143741

BC143747

BC143749

CAB000276

CAB025522

CCDS2394

CCDS42811

E9PDR1

ENSG00000178568

ENSP00000342235

ENSP00000403204

ENST00000342788

ENST00000436443

EntrezGene:2066

ERBB4

ERBB4-202

ERBB4-205

g4885214_3p_at

GE54083

GE575885

GE79117

GO:0000165

GO:0000166

GO:0001755

GO:0001934

GO:0003674

GO:0003677

GO:0004672

GO:0004713

GO:0004714

GO:0004888

GO:0005088

GO:0005154

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005759

GO:0005829

GO:0005886

GO:0005887

GO:0006464

GO:0006468

GO:0006629

GO:0006810

GO:0006915

GO:0006950

GO:0007005

GO:0007165

GO:0007169

GO:0007275

GO:0007399

GO:0007507

GO:0007595

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008285

GO:0009058

GO:0009790

GO:0009880

GO:0009925

GO:0009968

GO:0014068

GO:0016020

GO:0016021

GO:0016301

GO:0016310

GO:0016323

GO:0016477

GO:0016740

GO:0018108

GO:0019899

GO:0021551

GO:0021889

GO:0030154

GO:0030334

GO:0032991

GO:0034641

GO:0038128

GO:0040007

GO:0040011

GO:0042531

GO:0042803

GO:0043066

GO:0043167

GO:0043226

GO:0043235

GO:0043410

GO:0043653

GO:0044212

GO:0045165

GO:0045211

GO:0045893

GO:0046427

GO:0046777

GO:0046854

GO:0046934

GO:0048856

GO:0048870

GO:0051897

GO:0060045

GO:0060644

GO:0060749

GO:0061026

GO:0070374

GO:0071364

GO:2000010

GO:2000145

GO:2001223

HGNC:3432

HPA012016

Hs.7888.0.S1_3p_at

ILMN_1653728

ILMN_1661857

IPR000494

IPR000719

IPR001245

IPR006211

IPR006212

IPR008266

IPR009030

IPR011009

IPR016245

IPR017441

IPR020635

IPR032778

IPR036941

L07868

L07868_at

MIM:600543

MIM:615515

NM_001042599

NM_005235

NP_001036064

NP_005226

PF00757

PF01030

PF07714

PF14843

PH_hs_0000259

PR00109

SM00219

SM00261

TC02002735.hg

uc002veg.2

uc002veh.2

UPI00000499DF

UPI0000579525

XM_005246376

XM_005246377

XM_006712364

XM_017003577

XM_017003578

XM_017003579

XM_017003580

XM_017003581

XM_017003582

XP_005246433

XP_005246434

XP_006712427

XP_016859066

XP_016859067

XP_016859068

XP_016859069

XP_016859070

XP_016859071

Participant Of

hasComponent

ERBB4jmAcyt2s80 dimer [mitochondrial matrix]

Other forms of this molecule

ERBB4jmAcyt2s80 [nucleoplasm]

ERBB4jmAcyt2ECD [extracellular region]

ERBB4jmAcyt2m80 [plasma membrane]

ERBB4jmAcyt2s80 [cytosol]

p-Y1172,Y1226-ERBB4 JM-A CYT-2 isoform [plasma membrane]

ERBB4 JM-A CYT-2 isoform [plasma membrane]

Inferred To

Homologues of ERBB4jmAcyt2s80 [mitochondrial matrix] (Bos taurus)

Homologues of ERBB4jmAcyt2s80 [mitochondrial matrix] (Danio rerio)

Homologues of ERBB4jmAcyt2s80 [mitochondrial matrix] (Gallus gallus)

Homologues of ERBB4jmAcyt2s80 [mitochondrial matrix] (Sus scrofa)

phospho-ERBB4jmAcyt2s80 [mitochondrial matrix] (Bos taurus)

phospho-ERBB4jmAcyt2s80 [mitochondrial matrix] (Caenorhabditis elegans)

phospho-ERBB4jmAcyt2s80 [mitochondrial matrix] (Canis familiaris)

phospho-ERBB4jmAcyt2s80 [mitochondrial matrix] (Danio rerio)

phospho-ERBB4jmAcyt2s80 [mitochondrial matrix] (Drosophila melanogaster)

phospho-ERBB4jmAcyt2s80 [mitochondrial matrix] (Gallus gallus)

phospho-ERBB4jmAcyt2s80 [mitochondrial matrix] (Mus musculus)

phospho-ERBB4jmAcyt2s80 [mitochondrial matrix] (Rattus norvegicus)

phospho-ERBB4jmAcyt2s80 [mitochondrial matrix] (Sus scrofa)

phospho-ERBB4jmAcyt2s80 [mitochondrial matrix] (Taeniopygia guttata)

phospho-ERBB4jmAcyt2s80 [mitochondrial matrix] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 1172

Coordinate

1172

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1226

Coordinate

1226

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_005246433.1, NP_005226.1, XP_005246434.1, NP_001036064.1

ZINC - World Drugs

ERBB4_HUMAN

OpenTargets

ENSG00000178568

ZINC - FDA approved

ERBB4_HUMAN

ZINC - Substances

ERBB4_HUMAN

ZINC - Biogenic

ERBB4_HUMAN

ZINC target

Q15303

PRO

Q15303

PDB

2L2T, 3U9U, 2LCX, 3BBW, 3U7U, 3BBT, 2R4B, 3U2P, 2AHX, 3BCE

GeneCards

Q15303

BRENDA (Homo sapiens)

2.7.10.1

Orphanet

22474

ZINC - Predictions - Purchasable

ERBB4_HUMAN

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04626 ERBB2	12	p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) ERBB2 [plasma membrane] (R-HSA-372889) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.778	4
UniProt:P78352 DLG4	3	DLG4 [plasma membrane] (R-HSA-202135) DLG4 [cytosol] (R-HSA-6794267) DLG4 [endocytic vesicle membrane] (R-HSA-416847)	0.646	6
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321)	0.609	6
UniProt:Q13895 BYSL	2	BYSL [cytosol] (R-HSA-6791518) BYSL [nucleoplasm] (R-HSA-6791526)	0.577	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.573	7
UniProt:P08238 HSP90AB1	5	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617)	0.524	2