ERBB4s80 binds STAT5A

Stable Identifier
R-HSA-1254291
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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ERBB4s80 binds STAT5A through STAT5A SH2 domain. This interaction likely depends on STAT5A activation induced by prolactin and mediated by JAK2. Heterodimers of prolactin receptor (PRLR) and JAK2 are activated by prolactin binding, resulting in STAT5 recruitment and phosphorylation, and subsequent formation of phosphorylated STAT5 homodimers. There is evidence that ERBB4 may be part of the PRLR:JAK2 complex and that it may be activated by JAK2-mediated phosphorylation, in the absence of ERBB4 growth factors (Muraoka-Cook et al. 2008).

Literature References
PubMed ID Title Journal Year
18653779 Prolactin and ErbB4/HER4 signaling interact via Janus kinase 2 to induce mammary epithelial cell gene expression differentiation

Muraoka-Cook, RS, Sandahl, MA, Hunter, D, Miraglia, L, Earp HS, 3rd

Mol Endocrinol 2008
15534001 The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone

Williams, CC, Allison, JG, Vidal, GA, Burow, ME, Beckman, BS, Marrero, L, Jones, FE

J Cell Biol 2004
Participants
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Orthologous Events
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