Translocation of ERBB4s80:YAP1 complex to the nucleus

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
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Upon formation of ERBB4s80:YAP1 complex in the cytosol, the complex translocates to the nucleus, where it may act as a regulator of transcription (Komuro et al. 2003, Omerovic et al. 2004, Aqeilan et al. 2005).

Literature References
PubMed ID Title Journal Year
12807903 WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus

Navin, NE, Sudol, M, Komuro, A, Nagai, M

J Biol Chem 2003
16061658 WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function

Trapasso, F, Kaou, M, Pekarsky, Y, Donati, V, Aqeilan, RI, Croce, CM, Sudol, M, Palamarchuk, A

Cancer Res 2005
15023535 Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level

Fraioli, R, Frati, L, Puggioni, EM, Gulino, A, Alimandi, M, Omerovic, J, Napoletano, S, Visco, V

Exp Cell Res 2004
Orthologous Events
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