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4xHC-TIMM9 [mitochondrial inner membrane]
Stable Identifier
R-HSA-1252069
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
TIMM9 (disulfide-bonded), Mitochondrial import inner membrane translocase subunit Tim9, TIM9_HUMAN, TIMM9
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Mitochondrial protein degradation (Homo sapiens)
YME1L1 binds mitochondrial inner membrane proteins (Homo sapiens)
Substrate of YME1L1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
4xHC-TIMM9 [mitochondrial inner membrane] (Homo sapiens)
YME1L1:substrate protein (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
Substrate of YME1L1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
4xHC-TIMM9 [mitochondrial inner membrane] (Homo sapiens)
YME1L1 degrades mitochondrial inner membrane proteins (Homo sapiens)
YME1L1:substrate protein (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
Substrate of YME1L1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
4xHC-TIMM9 [mitochondrial inner membrane] (Homo sapiens)
Protein localization (Homo sapiens)
Mitochondrial protein import (Homo sapiens)
TIMM9:TIMM10 binds hydrophobic proteins (Homo sapiens)
TIMM9:TIMM10 [mitochondrial inner membrane] (Homo sapiens)
4xHC-TIMM9 [mitochondrial inner membrane] (Homo sapiens)
TIMM9:TIMM10:Protein [mitochondrial inner membrane] (Homo sapiens)
TIMM9:TIMM10 [mitochondrial inner membrane] (Homo sapiens)
4xHC-TIMM9 [mitochondrial inner membrane] (Homo sapiens)
TIMM9:TIMM10 transfers proteins to TIMM22 (Homo sapiens)
TIMM9:TIMM10:Protein [mitochondrial inner membrane] (Homo sapiens)
TIMM9:TIMM10 [mitochondrial inner membrane] (Homo sapiens)
4xHC-TIMM9 [mitochondrial inner membrane] (Homo sapiens)
TIMM9:TIMM10:TIMM10B:TIM22:Protein [mitochondrial inner membrane] (Homo sapiens)
TIMM9:TIMM10:TIMM10B [mitochondrial inner membrane] (Homo sapiens)
4xHC-TIMM9 [mitochondrial inner membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
16387659
Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller
Gorman, MA
,
Gulbis, JM
,
Ryan, MT
,
Lazarou, M
,
Webb, CT
Mol Cell
2006
External Reference Information
External Reference
UniProt:Q9Y5J7 TIMM9
Gene Names
TIMM9, TIM9, TIM9A, TIMM9A
Chain
initiator methionine:, chain:2-89
Reference Genes
BioGPS Gene:26520 TIMM9
COSMIC (genes):TIMM9 TIMM9
CTD Gene:26520 TIMM9
dbSNP Gene:26520 TIMM9
ENSEMBL:ENSG00000100575 TIMM9
ENSEMBL_homo_sapiens_GENE:ENSG00000100575.14 TIMM9
HGNC:11819 TIMM9
KEGG Gene (Homo sapiens):26520 TIMM9
Monarch:26520 TIMM9
NCBI Gene:26520 TIMM9
OMIM:607384 TIMM9
UCSC:Q9Y5J7 TIMM9
Reference Transcript
RefSeq:NM_001304487.1 TIMM9
RefSeq:NM_001304486.1 TIMM9
RefSeq:NM_012460.3 TIMM9
RefSeq:NM_001304485.1 TIMM9
RefSeq:NM_001304491.1 TIMM9
RefSeq:NM_001304489.1 TIMM9
RefSeq:NM_001304490.1 TIMM9
RefSeq:NM_001304488.1 TIMM9
Other Identifiers
11720797_a_at
16793460
218316_PM_at
218316_at
239080_PM_at
239080_at
26520
3566655
3566656
3566657
3566658
3566659
3566660
3566664
3566666
3566667
3566668
3566669
3566670
3566671
54258_r_at
7979416
A_23_P76918
GE849447
GO:0005515
GO:0005739
GO:0005743
GO:0005758
GO:0006626
GO:0006886
GO:0007005
GO:0007605
GO:0008270
GO:0015031
GO:0016020
GO:0032977
GO:0042719
GO:0042721
GO:0042803
GO:0043226
GO:0045039
GO:0046872
GO:0050877
GO:0051087
GO:0061024
GO:0140104
HMNXSV003039482
Hs.264079.0.A1_3p_at
ILMN_1653709
PH_hs_0025792
PH_hs_0038114
TC14001178.hg
g6912713_3p_at
Participates
as a member of
Substrate of YME1L1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
as a component of
TIMM9:TIMM10:TIMM10B [mitochondrial inner membrane] (Homo sapiens)
TIMM9:TIMM10 [mitochondrial inner membrane] (Homo sapiens)
Inferred To
TIM9 [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
timm9 [mitochondrial inner membrane]
(Danio rerio)
timm9 [mitochondrial inner membrane]
(Dictyostelium discoideum)
timm9 [mitochondrial inner membrane]
(Xenopus tropicalis)
4xHC-TIMM9 [mitochondrial inner membrane]
(Plasmodium falciparum)
4xHC-TIMM9 [mitochondrial inner membrane]
(Sus scrofa)
TIMM9 [mitochondrial inner membrane]
(Bos taurus)
TIMM9 [mitochondrial inner membrane]
(Canis familiaris)
TIMM9 [mitochondrial inner membrane]
(Gallus gallus)
Tim9a [mitochondrial inner membrane]
(Drosophila melanogaster)
tim9 [mitochondrial inner membrane]
(Schizosaccharomyces pombe)
tin-9.1 [mitochondrial inner membrane]
(Caenorhabditis elegans)
Modified Residues
Name
Intra-chain Crosslink via L-cystine (cross-link) at 28 and 52
Coordinate
28
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Name
Intra-chain Crosslink via L-cystine (cross-link) at 32 and 48
Coordinate
32
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
RefSeq
NP_001291418.1
,
NP_036592.1
,
NP_001291415.1
,
NP_001291417.1
,
NP_001291419.1
,
NP_001291414.1
,
NP_001291420.1
,
NP_001291416.1
OpenTargets
ENSG00000100575
HPA
ENSG00000100575-TIMM9
GeneCards
Q9Y5J7
Ensembl
ENST00000555061
,
ENSP00000450638
,
ENST00000555593
,
ENSP00000378588
,
ENST00000395159
,
ENST00000555404
,
ENSG00000100575
,
ENSP00000451006
,
ENSP00000451198
PRO
Q9Y5J7
Pharos - Targets
Q9Y5J7
PDB
7CGP
,
2BSK
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5J6 TIMM10B
1
4xHC-TIMM10B [mitochondrial inner membrane]
(R-HSA-1252043)
0.499
5
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