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4xHC-TIMM8A [mitochondrial intermembrane space]
Stable Identifier
R-HSA-1252065
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial intermembrane space
Synonyms
TIMM8A (disulfide-bonded), Mitochondrial import inner membrane translocase subunit Tim8 A, TIM8A_HUMAN, TIMM8A
Locations in the PathwayBrowser
Expand all
Protein localization (Homo sapiens)
Mitochondrial protein import (Homo sapiens)
MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds (Homo sapiens)
Products of MIA40:ERV1 [mitochondrial intermembrane space] (Homo sapiens)
4xHC-TIMM8A [mitochondrial intermembrane space] (Homo sapiens)
TIMM8:TIMM13 chaperones hydrophobic proteins (Homo sapiens)
TIMM8:TIMM13 [mitochondrial intermembrane space] (Homo sapiens)
TIMM8A:TIMM13 [mitochondrial intermembrane space] (Homo sapiens)
4xHC-TIMM8A [mitochondrial intermembrane space] (Homo sapiens)
TIMM8:TIMM13:Protein [mitochondrial intermembrane space] (Homo sapiens)
TIMM8:TIMM13 [mitochondrial intermembrane space] (Homo sapiens)
TIMM8A:TIMM13 [mitochondrial intermembrane space] (Homo sapiens)
4xHC-TIMM8A [mitochondrial intermembrane space] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60220 TIMM8A
Gene Names
TIMM8A, DDP, DDP1, TIM8A
Chain
chain:1-97
Reference Genes
BioGPS Gene:1678 TIMM8A
COSMIC (genes):TIMM8A TIMM8A
CTD Gene:1678 TIMM8A
dbSNP Gene:1678 TIMM8A
ENSEMBL:ENSG00000126953 TIMM8A
ENSEMBL_homo_sapiens_GENE:ENSG00000126953.8 TIMM8A
HGNC:11817 TIMM8A
KEGG Gene (Homo sapiens):1678 TIMM8A
Monarch:1678 TIMM8A
NCBI Gene:1678 TIMM8A
OMIM:300356 TIMM8A
UCSC:O60220 TIMM8A
Reference Transcript
RefSeq:NM_004085.3 TIMM8A
Other Identifiers
11727861_at
1678
17112729
205217_PM_at
205217_at
2584088
2584090
2584091
39882_at
4015698
4015699
4015700
4015704
8174047
A_23_P358417
GE59324
GE80499
GO:0005515
GO:0005739
GO:0005743
GO:0005758
GO:0006886
GO:0007005
GO:0007399
GO:0015031
GO:0016020
GO:0042719
GO:0042802
GO:0043226
GO:0045039
GO:0046872
GO:0048856
GO:0061024
HMNXSV003023185
HMNXSV003032904
ILMN_1722239
PH_hs_0030358
PH_hs_0033622
g6138974_3p_at
Participates
as a candidate of
Products of MIA40:ERV1 [mitochondrial intermembrane space] (Homo sapiens)
as a component of
TIMM8A:TIMM13 [mitochondrial intermembrane space] (Homo sapiens)
Other forms of this molecule
TIMM8A [mitochondrial intermembrane space]
Inferred From
4xHC-TIM8 [mitochondrial intermembrane space]
(Saccharomyces cerevisiae)
Modified Residues
Name
Intra-chain Crosslink via L-cystine (cross-link) at 43 and 66
Coordinate
43
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Name
Intra-chain Crosslink via L-cystine (cross-link) at 47 and 62
Coordinate
47
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
RefSeq
NP_004076.1
OpenTargets
ENSG00000126953
GeneCards
O60220
HPA
ENSG00000126953-TIMM8A
Ensembl
ENSP00000361993
,
ENST00000372902
,
ENSG00000126953
PRO
O60220
Pharos - Targets
O60220
Orphanet
15620
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q99856 ARID3A
1
ARID3A [nucleoplasm]
(R-HSA-3782552)
0.556
3
UniProt:Q53GS7 GLE1
1
GLE1 [nucleoplasm]
(R-HSA-8932905)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
15
UniProt:Q99558 MAP3K14
5
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
0.527
2
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