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4xHC-TIMM10 [mitochondrial inner membrane]
Stable Identifier
R-HSA-1252060
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
TIMM10 (disulfide-bonded), Mitochondrial import inner membrane translocase subunit Tim10, TIM10_HUMAN, TIMM10
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Mitochondrial protein degradation (Homo sapiens)
YME1L1 binds mitochondrial inner membrane proteins (Homo sapiens)
Substrate of YME1L1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
4xHC-TIMM10 [mitochondrial inner membrane] (Homo sapiens)
YME1L1:substrate protein (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
Substrate of YME1L1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
4xHC-TIMM10 [mitochondrial inner membrane] (Homo sapiens)
YME1L1 degrades mitochondrial inner membrane proteins (Homo sapiens)
YME1L1:substrate protein (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
Substrate of YME1L1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
4xHC-TIMM10 [mitochondrial inner membrane] (Homo sapiens)
Protein localization (Homo sapiens)
Mitochondrial protein import (Homo sapiens)
TIMM9:TIMM10 binds hydrophobic proteins (Homo sapiens)
TIMM9:TIMM10 [mitochondrial inner membrane] (Homo sapiens)
4xHC-TIMM10 [mitochondrial inner membrane] (Homo sapiens)
TIMM9:TIMM10:Protein [mitochondrial inner membrane] (Homo sapiens)
TIMM9:TIMM10 [mitochondrial inner membrane] (Homo sapiens)
4xHC-TIMM10 [mitochondrial inner membrane] (Homo sapiens)
TIMM9:TIMM10 transfers proteins to TIMM22 (Homo sapiens)
TIMM9:TIMM10:Protein [mitochondrial inner membrane] (Homo sapiens)
TIMM9:TIMM10 [mitochondrial inner membrane] (Homo sapiens)
4xHC-TIMM10 [mitochondrial inner membrane] (Homo sapiens)
TIMM9:TIMM10:TIMM10B:TIM22:Protein [mitochondrial inner membrane] (Homo sapiens)
TIMM9:TIMM10:TIMM10B [mitochondrial inner membrane] (Homo sapiens)
4xHC-TIMM10 [mitochondrial inner membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
16387659
Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller
Gorman, MA
,
Gulbis, JM
,
Ryan, MT
,
Lazarou, M
,
Webb, CT
Mol Cell
2006
External Reference Information
External Reference
UniProt:P62072 TIMM10
Gene Names
TIMM10, TIM10
Chain
chain:1-90
Reference Genes
BioGPS Gene:26519 TIMM10
COSMIC (genes):TIMM10 TIMM10
CTD Gene:26519 TIMM10
dbSNP Gene:26519 TIMM10
ENSEMBL:ENSG00000134809 TIMM10
HGNC:11814 TIMM10
KEGG:hsa:26519 TIMM10
Monarch:26519 TIMM10
NCBI Gene:26519 TIMM10
OMIM:602251 TIMM10
UCSC:P62072 TIMM10
Reference Transcript
RefSeq:NM_012456.2 TIMM10
Other Identifiers
11743283_a_at
1555764_PM_s_at
1555764_s_at
16738536
218408_PM_at
218408_at
26519
3373947
3373948
3373949
3373950
3373951
3373952
3373953
3373954
48109_at
52896_at
7948267
A_23_P64343
GE58499
GO:0005515
GO:0005739
GO:0005743
GO:0005744
GO:0005758
GO:0006626
GO:0006886
GO:0007005
GO:0007605
GO:0008270
GO:0015031
GO:0032977
GO:0042719
GO:0042721
GO:0042803
GO:0043226
GO:0045039
GO:0046872
GO:0050877
GO:0051087
GO:0061024
GO:0140104
HMNXSV003016131
Hs2.235750.2.S1_3p_s_at
ILMN_1765332
TC11001794.hg
g6912707_3p_at
Participates
as a member of
Substrate of YME1L1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
as a component of
TIMM9:TIMM10:TIMM10B [mitochondrial inner membrane] (Homo sapiens)
TIMM9:TIMM10 [mitochondrial inner membrane] (Homo sapiens)
Inferred To
timm10 [mitochondrial inner membrane]
(Danio rerio)
timm10 [mitochondrial inner membrane]
(Dictyostelium discoideum)
Ghost homologue of 4xHC-TIMM10 [mitochondrial inner membrane]
(Xenopus tropicalis)
TIM10 [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
TIMM10 [mitochondrial inner membrane]
(Bos taurus)
TIMM10 [mitochondrial inner membrane]
(Canis familiaris)
TIMM10 [mitochondrial inner membrane]
(Gallus gallus)
Tim10 [mitochondrial inner membrane]
(Drosophila melanogaster)
tin-10 [mitochondrial inner membrane]
(Caenorhabditis elegans)
tim10 [mitochondrial inner membrane]
(Schizosaccharomyces pombe)
4xHC-TIMM10 [mitochondrial inner membrane]
(Plasmodium falciparum)
4xHC-TIMM10 [mitochondrial inner membrane]
(Sus scrofa)
Modified Residues
Name
Intra-chain Crosslink via L-cystine (cross-link) at 29 and 54
Coordinate
29
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Name
Intra-chain Crosslink via L-cystine (cross-link) at 33 and 50
Coordinate
33
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
ENSEMBL
ENSP00000433627
,
ENSP00000257245
,
ENST00000525158
,
ENSP00000435678
,
ENST00000257245
,
ENST00000525587
OpenTargets
ENSG00000134809
HPA
ENSG00000134809-TIMM10
PRO
P62072
Pharos - Targets
P62072
GlyGen
P62072
PDB
7CGP
,
2BSK
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5J6 TIMM10B
1
4xHC-TIMM10B [mitochondrial inner membrane]
(R-HSA-1252043)
0.623
6
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