Reactome | 4xHC-TIMM10B [mitochondrial inner membrane]

4xHC-TIMM10B [mitochondrial inner membrane]

Stable Identifier

R-HSA-1252043

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

FXC1 (TIM9B) (TIM10B), Mitochondrial import inner membrane translocase subunit Tim9 B, TIM9B_HUMAN, FXC1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y5J6 TIMM10B

Gene Names

TIMM10B, FXC1, TIM9B, TIMM9B

Chain

chain:1-103

Reference Genes

BioGPS Gene:26515 TIMM10B

COSMIC (genes):TIMM10B TIMM10B

CTD Gene:26515 TIMM10B

dbSNP Gene:26515 TIMM10B

ENSEMBL:ENSG00000132286 TIMM10B

ENSEMBL_homo_sapiens_GENE:ENSG00000132286.12 TIMM10B

HGNC:4022 TIMM10B

KEGG Gene (Homo sapiens):26515 TIMM10B

Monarch:26515 TIMM10B

NCBI Gene:26515 TIMM10B

OMIM:607388 TIMM10B

UCSC:Q9Y5J6 TIMM10B

Reference Transcript

RefSeq:NM_012192.3 TIMM10B

Other Identifiers

11719919_a_at

11719920_at

11753807_a_at

11757655_a_at

16721393

217981_PM_s_at

217981_s_at

222481_PM_at

222481_at

26515

3318715

3318717

3318718

3318719

3318720

3318721

3318722

3318723

3318724

45813_at

45814_at

7938111

A_14_P125654

A_23_P127851

A_33_P3243657

GE58469

GO:0005215

GO:0005515

GO:0005739

GO:0005743

GO:0005758

GO:0006886

GO:0007005

GO:0007155

GO:0007160

GO:0015031

GO:0016020

GO:0042719

GO:0042721

GO:0043226

GO:0045039

GO:0046872

GO:0051082

GO:0061024

GO:0140318

HMNXSV003009868

Hs.54943.0.S3_3p_at

ILMN_1773850

PH_hs_0003605

g6912381_3p_a_at

Participates

as a component of

TIMM9:TIMM10:TIMM10B [mitochondrial inner membrane] (Homo sapiens)

as an input of

TIMM9:TIMM10 transfers proteins to TIMM22 (Homo sapiens)

Inferred From

4xHC-TIM9 [mitochondrial intermembrane space] (Saccharomyces cerevisiae)

Inferred To

TIMM10B [mitochondrial inner membrane] (Canis familiaris)

TIMM10B [mitochondrial inner membrane] (Gallus gallus)

TIMM10B [mitochondrial inner membrane] (Sus scrofa)

TIM9 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

timm9 [mitochondrial inner membrane] (Dictyostelium discoideum)

Tim9b [mitochondrial inner membrane] (Drosophila melanogaster)

timm10b [mitochondrial inner membrane] (Danio rerio)

timm10b [mitochondrial inner membrane] (Xenopus tropicalis)

4xHC-TIMM10B [mitochondrial inner membrane] (Bos taurus)

4xHC-TIMM10B [mitochondrial inner membrane] (Plasmodium falciparum)

tim9 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

Modified Residues

Name

Intra-chain Crosslink via L-cystine (cross-link) at 28 and 52

Coordinate

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Name

Intra-chain Crosslink via L-cystine (cross-link) at 32 and 48

Coordinate

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Cross References

RefSeq

NP_036324.1

OpenTargets

ENSG00000132286

GeneCards

Q9Y5J6

HPA

ENSG00000132286-TIMM10B

Ensembl

ENSP00000436948, ENSG00000132286, ENST00000254616, ENSP00000254616, ENST00000533379

PRO

Q9Y5J6

Pharos - Targets

Q9Y5J6

PDB

7CGP

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62072 TIMM10	1	4xHC-TIMM10 [mitochondrial inner membrane] (R-HSA-1252060)	0.623	6
UniProt:O14770-4 MEIS2			0.556	3
UniProt:Q2WGJ6 KLH38			0.556	3
UniProt:O95983-2 MBD3			0.556	3
UniProt:O00303 EIF3F	1	EIF3F [cytosol] (R-HSA-72540)	0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:P18509 ADCYAP1	4	ADCYAP1(132-158) [extracellular region] (R-HSA-420144) ADCYAP1(82-129) [extracellular region] (R-HSA-420254) ADCYAP1(132-169) [extracellular region] (R-HSA-420282) ADCYAP1(2-742) [Golgi membrane] (R-HSA-187679)	0.527	2
UniProt:P0DTD1-PRO_0000449622 REP			0.527	2
UniProt:Q53H12 AGK	3	AGK [mitochondrial outer membrane] (R-HSA-5696027) AGK(1-33)InsW-BRAF(328-766) fusion [cytosol] (R-HSA-6802260) AGK(1-33)InsW-p-BRAF(328-766) fusion [cytosol] (R-HSA-6802510)	0.527	4
UniProt:Q9Y5J7 TIMM9	1	4xHC-TIMM9 [mitochondrial inner membrane] (R-HSA-1252069)	0.499	5
UniProt:Q96DH6 MSI2	1	MSI2 [cytosol] (R-HSA-9715155)	0.499	2

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