Translocation of ERBB4s80 to the nucleus

Stable Identifier
R-HSA-1252013
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
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The soluble intracellular domain of ERBB4 s80 (E4ICD) is able to translocate from the cytosol to the nucleus (Ni et al. 2001). Translocation of ERBB4s80 to the nucleus is negatively regulated by binding of ERBB4s80 to activated SRC kinase (Ishibashi et al. 2012).

Literature References
PubMed ID Title Journal Year
23230144 Nuclear ErbB4 signaling through H3K9me3 is antagonized by EGFR-activated c-Src

Kubota, S, Hasegawa, H, Ishibashi, K, Fukumoto, Y, Yamaguchi, N, Nakayama, Y, Abe, K, Kubota, S, Aoyama, K

J. Cell. Sci. 2013
11679632 gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

Golde, TE, Murphy, MP, Carpenter, G, Ni, CY

Science 2001
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