Reactome | ERBB4jmAcyt2s80 [cytosol]

ERBB4jmAcyt2s80 [cytosol]

Stable Identifier

R-HSA-1251987

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-Y1172,Y1226-ERBB4-3(676-1292)

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External Reference Information

External Reference

UniProt:Q15303-3 ERBB4

Gene Names

ERBB4, HER4

Other Identifiers

0002120022

0100580450

11725911_a_at

11725912_a_at

11725913_a_at

12016

16907863

1727_at

2066

206794_at

214053_at

25522

2597563

2597564

2597565

2597566

2597567

2597568

2597569

2597570

2597571

2597580

2597581

2597583

2597584

2597586

2597609

2597615

2597616

2597617

2597621

2597626

2597628

2597629

2597631

2597632

2597633

2597635

2597636

2597637

2597638

2597646

2597661

2597684

2597720

2597788

2597789

276

2AHX

2L2T

2LCX

2R4B

37273_at

3BBT

3BBW

3BCE

3U2P

3U7U

3U9U

8058627

92081_at

A0A0A0MSE1

A_23_P423853

A_32_P183765

A_33_P3211558

AAB59446

AAI12200

AAI43742

AAI43748

AAI43750

AB209697

BAD92934

BC112199

BC143741

BC143747

BC143749

CAB000276

CAB025522

CCDS2394

CCDS42811

E9PDR1

ENSG00000178568

ENSP00000342235

ENSP00000403204

ENST00000342788

ENST00000342788.8

ENST00000436443

ENST00000436443.5

EntrezGene:2066

EntrezGene:ERBB4

ERBB4

ERBB4-202

ERBB4-205

g4885214_3p_at

GE54083

GE575885

GE79117

GO:0000165

GO:0000166

GO:0001755

GO:0001934

GO:0003674

GO:0003677

GO:0004672

GO:0004713

GO:0004714

GO:0005154

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005759

GO:0005829

GO:0005886

GO:0005887

GO:0006464

GO:0006468

GO:0006810

GO:0006915

GO:0006950

GO:0007005

GO:0007165

GO:0007169

GO:0007275

GO:0007399

GO:0007416

GO:0007507

GO:0007595

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008285

GO:0009058

GO:0009790

GO:0009880

GO:0009925

GO:0014068

GO:0016020

GO:0016021

GO:0016301

GO:0016310

GO:0016323

GO:0016477

GO:0016740

GO:0018108

GO:0021551

GO:0021889

GO:0022607

GO:0030154

GO:0030334

GO:0032991

GO:0034641

GO:0038128

GO:0040007

GO:0040011

GO:0042531

GO:0042803

GO:0043167

GO:0043226

GO:0043235

GO:0043653

GO:0044212

GO:0045165

GO:0045211

GO:0045893

GO:0046427

GO:0046777

GO:0048856

GO:0048870

GO:0051897

GO:0060045

GO:0060644

GO:0060749

GO:0061026

GO:0070374

GO:0071364

GO:0098978

GO:0098982

GO:0099056

GO:0099061

GO:2000010

GO:2000145

GO:2001223

HGNC:3432

HPA012016

Hs.7888.0.S1_3p_at

ILMN_1653728

ILMN_1661857

IPR000494

IPR000719

IPR001245

IPR006211

IPR006212

IPR008266

IPR009030

IPR011009

IPR016245

IPR017441

IPR020635

IPR032778

IPR036941

L07868

L07868_at

MIM:600543

MIM:615515

NM_001042599

NM_005235

NP_001036064

NP_005226

PF00757

PF01030

PF07714

PF14843

PH_hs_0000259

PR00109

SM00219

SM00261

TC02002735.hg

UPI00000499DF

UPI0000579525

XM_005246376

XM_005246377

XM_006712364

XM_017003577

XM_017003578

XM_017003579

XM_017003580

XM_017003581

XM_017003582

XP_005246433

XP_005246434

XP_006712427

XP_016859066

XP_016859067

XP_016859068

XP_016859069

XP_016859070

XP_016859071

Participant Of

hasComponent

ERBB4jmAcyt2s80 dimer [cytosol]

Other forms of this molecule

ERBB4jmAcyt2s80 [mitochondrial matrix]

ERBB4jmAcyt2s80 [nucleoplasm]

ERBB4jmAcyt2ECD [extracellular region]

ERBB4jmAcyt2m80 [plasma membrane]

p-Y1172,Y1226-ERBB4 JM-A CYT-2 isoform [plasma membrane]

ERBB4 JM-A CYT-2 isoform [plasma membrane]

Inferred To

phospho-ERBB4jmAcyt2s80 [cytosol] (Bos taurus)

phospho-ERBB4jmAcyt2s80 [cytosol] (Caenorhabditis elegans)

phospho-ERBB4jmAcyt2s80 [cytosol] (Canis familiaris)

phospho-ERBB4jmAcyt2s80 [cytosol] (Danio rerio)

phospho-ERBB4jmAcyt2s80 [cytosol] (Drosophila melanogaster)

phospho-ERBB4jmAcyt2s80 [cytosol] (Gallus gallus)

phospho-ERBB4jmAcyt2s80 [cytosol] (Mus musculus)

phospho-ERBB4jmAcyt2s80 [cytosol] (Rattus norvegicus)

phospho-ERBB4jmAcyt2s80 [cytosol] (Sus scrofa)

phospho-ERBB4jmAcyt2s80 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 1172

Coordinate

1172

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1226

Coordinate

1226

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001036064.1, XP_005246433.1, NP_005226.1, XP_005246434.1

ZINC - World Drugs

ERBB4_HUMAN

OpenTargets

ENSG00000178568

ZINC - FDA approved

ERBB4_HUMAN

ZINC - Substances

ERBB4_HUMAN

ZINC target

Q15303

ZINC - Biogenic

ERBB4_HUMAN

PRO

Q15303

PDB

3BCE, 2LCX, 3U2P, 3U9U, 3BBT, 3BBW, 2L2T, 2R4B, 2AHX, 3U7U

ZINC - Investigational

ERBB4_HUMAN

GeneCards

Q15303

Orphanet

22474

ZINC - Predictions - Purchasable

ERBB4_HUMAN

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04626 ERBB2	91	p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) p-Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 L755W [plasma membrane] (R-HSA-9654193) p-Y-ERBB2 T733I [plasma membrane] (R-HSA-9654610) p-Y-ERBB2 H878R [plasma membrane] (R-HSA-9654835) p-Y-ERBB2 L869R [plasma membrane] (R-HSA-9654730) p-Y-ERBB2 G776S [plasma membrane] (R-HSA-9664608) p-Y-ERBB2 L869Q [plasma membrane] (R-HSA-9654732) p-Y-ERBB2 G776L [plasma membrane] (R-HSA-9664600) p-Y-ERBB2 G776V [plasma membrane] (R-HSA-9664602) p-Y-ERBB2 G776C [plasma membrane] (R-HSA-9664611) ERBB2 D769Y [plasma membrane] (R-HSA-9646620) ERBB2 L755P [plasma membrane] (R-HSA-9646494) ERBB2 V842I [plasma membrane] (R-HSA-9646703) ERBB2 H878Y [plasma membrane] (R-HSA-9646824) ERBB2 T798M [plasma membrane] (R-HSA-9646825) ERBB2 D769H [plasma membrane] (R-HSA-9646617) ERBB2 T862A [plasma membrane] (R-HSA-9649434) ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665621) ERBB2 L755S [plasma membrane] (R-HSA-9646423) ERBB2 I767M [plasma membrane] (R-HSA-9646737) ERBB2 V777L [plasma membrane] (R-HSA-9646579) ERBB2 D769N [plasma membrane] (R-HSA-9646636) ERBB2 T733I [plasma membrane] (R-HSA-9646765) ERBB2 V777M [plasma membrane] (R-HSA-9646591) ERBB2 V777E [plasma membrane] (R-HSA-9646586) ERBB2 L755W [plasma membrane] (R-HSA-9646516) ERBB2 L755M [plasma membrane] (R-HSA-9646517) ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665622) ERBB2 H878R [plasma membrane] (R-HSA-9646822) ERBB2 V842E [plasma membrane] (R-HSA-9646710) ERBB2 T798I [plasma membrane] (R-HSA-9646823) ERBB2 R896C [plasma membrane] (R-HSA-9646714) ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9646667) ERBB2 R896H [plasma membrane] (R-HSA-9646728) ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665625) ERBB2 G776S [plasma membrane] (R-HSA-9664463) ERBB2 L869R [plasma membrane] (R-HSA-9646827) ERBB2 L869Q [plasma membrane] (R-HSA-9646828) ERBB2 G776C [plasma membrane] (R-HSA-9664457) ERBB2 G776L [plasma membrane] (R-HSA-9664454) ERBB2 G776V [plasma membrane] (R-HSA-9664450) p-6Y-ERBB2 V777L [plasma membrane] (R-HSA-9647214) p-6Y-ERBB2 H878Y [plasma membrane] (R-HSA-9647215) ERBB2 L755_T759del [plasma membrane] (R-HSA-9663599) p-6Y-ERBB2 R896C [plasma membrane] (R-HSA-9647208) p-6Y-ERBB2 V842I [plasma membrane] (R-HSA-9647209) p-6Y-ERBB2 I767M [plasma membrane] (R-HSA-9647211) p-6Y-ERBB2 T862A [plasma membrane] (R-HSA-9654692) p-6Y-ERBB2 D769H [plasma membrane] (R-HSA-9647200) p-6Y-ERBB2 T798I [plasma membrane] (R-HSA-9647202) p-6Y-ERBB2 L755P [plasma membrane] (R-HSA-9647196) p-6Y-ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9647198) p-6Y-ERBB2 L755S [plasma membrane] (R-HSA-9647216) p-6Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665650) p-6Y-ERBB2 T798M [plasma membrane] (R-HSA-9647218) p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665644) p-6Y-ERBB2 D769Y [plasma membrane] (R-HSA-9647199) p-6Y-ERBB2 V777E [plasma membrane] (R-HSA-9647210) p-6Y-ERBB2 T733I [plasma membrane] (R-HSA-9647195) p-6Y-ERBB2 L755M [plasma membrane] (R-HSA-9647204) p-6Y-ERBB2 V777M [plasma membrane] (R-HSA-9647205) p-6Y-ERBB2 V842E [plasma membrane] (R-HSA-9647206) p-6Y-ERBB2 D769N [plasma membrane] (R-HSA-9647207) p-6Y-ERBB2 R896H [plasma membrane] (R-HSA-9647217) p-6Y-ERBB2 L755W [plasma membrane] (R-HSA-9647201) p-6Y-ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665634) p-6Y-ERBB2 H878R [plasma membrane] (R-HSA-9647203) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) ERBB2 [plasma membrane] (R-HSA-372889) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.778	4
UniProt:P78352 DLG4	3	DLG4 [endocytic vesicle membrane] (R-HSA-416847) DLG4 [plasma membrane] (R-HSA-202135) DLG4 [cytosol] (R-HSA-6794267)	0.646	6
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.609	6
UniProt:Q13895 BYSL	2	BYSL [cytosol] (R-HSA-6791518) BYSL [nucleoplasm] (R-HSA-6791526)	0.577	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.573	7
UniProt:Q06124 PTPN11	4	PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y546-PTPN11 [cytosol] (R-HSA-1369081) p-Y546,Y584-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563)	0.573	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617)	0.524	2