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NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane]
Stable Identifier
R-HSA-1251958
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PI3K:p-ERBB4cyt1 [plasma membrane] (Homo sapiens)
p-ERBB4cyt1 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PI3K:p-ERBB4cyt1 [plasma membrane] (Homo sapiens)
p-ERBB4cyt1 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PI3K:p-ERBB4cyt1 [plasma membrane] (Homo sapiens)
p-ERBB4cyt1 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PI3K:p-ERBB4cyt1 [plasma membrane] (Homo sapiens)
p-ERBB4cyt1 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Homo sapiens)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Homo sapiens)
p-ERBB4 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4cyt1 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB4 (Homo sapiens)
PI3K events in ERBB4 signaling (Homo sapiens)
Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Homo sapiens)
PI3K:p-ERBB4cyt1 [plasma membrane] (Homo sapiens)
p-ERBB4cyt1 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
p-ERBB4cyt1 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Homo sapiens)
PI3K:p-ERBB4cyt1 [plasma membrane] (Homo sapiens)
p-ERBB4cyt1 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
SHC1 events in ERBB4 signaling (Homo sapiens)
Phosphorylation of SHC1 by ERBB4 homodimers (Homo sapiens)
SHC1:p-ERBB4 [plasma membrane] (Homo sapiens)
p-ERBB4 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4cyt1 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Homo sapiens)
p-ERBB4 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4cyt1 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Homo sapiens)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Homo sapiens)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Homo sapiens)
p-ERBB4 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4cyt1 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Homo sapiens)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Homo sapiens)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Homo sapiens)
p-ERBB4 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4cyt1 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Homo sapiens)
p-ERBB4 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4cyt1 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
SHC1 binds P-ERBB4 isoform dimers (Homo sapiens)
SHC1:p-ERBB4 [plasma membrane] (Homo sapiens)
p-ERBB4 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4cyt1 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
p-ERBB4 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4cyt1 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
Trans-autophosphorylation of ERBB4 homodimers (Homo sapiens)
p-ERBB4 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4cyt1 homodimers [plasma membrane] (Homo sapiens)
p-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
Participants
components
NRGs/EGF-like ligands [extracellular region]
(Homo sapiens)
p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform [plasma membrane]
(Homo sapiens)
Participates
as a component of
p-ERBB4jmBcyt1 [plasma membrane] (Homo sapiens)
Inferred To
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane]
(Bos taurus)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane]
(Canis familiaris)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane]
(Danio rerio)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane]
(Drosophila melanogaster)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane]
(Gallus gallus)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane]
(Mus musculus)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane]
(Rattus norvegicus)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane]
(Sus scrofa)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane]
(Xenopus tropicalis)
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