PLCG1 binds to p-ERBB2:p-EGFR

Stable Identifier
R-HSA-1251944
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
Synonyms
Phospholipase C gamma 1 (PLCG1) binds to phosphorylated ERBB2:EGFR heterodimer
ReviewStatus
5/5
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PLCG1 binds to p-ERBB2:p-EGFR
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Phospholipase C gamma 1 (PLCG1) binds to phosphorylated tyrosine Y1023 of ERBB2 or phosphorylated tyrosines Y992 and Y1173 of EGFR (Fazioli et al. 1991, Cohen et al. 1996, Chattopadhyay et al. 1999).

Literature References
PubMed ID Title Journal Year
8940074 The relationship between human epidermal growth-like factor receptor expression and cellular transformation in NIH3T3 cells

Fell, HP, Kiener, PA, Foy, L, Zhang, K, Green, JM, Cohen, BD

J Biol Chem 1996
10473558 The role of individual SH2 domains in mediating association of phospholipase C-gamma1 with the activated EGF receptor

Ji, Q, Mernaugh, R, Chattopadhyay, A, Vecchi, M, Carpenter, G

J Biol Chem 1999
1672440 The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency

Di Fiore, PP, Rhee, SG, Kim, UH, Fazioli, F, Segatto, O, Molloy, CJ

Mol Cell Biol 1991
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Output
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Inferred From
Plcg1 binds P-ERBB2:P-EGFR (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-04-25)
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