PLCG1 binds to p-ERBB2:p-EGFR

Stable Identifier
Reaction [binding]
Homo sapiens
Phospholipase C gamma 1 (PLCG1) binds to phosphorylated ERBB2:EGFR heterodimer
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Phospholipase C gamma 1 (PLCG1) binds to phosphorylated tyrosine Y1023 of ERBB2 or phosphorylated tyrosines Y992 and Y1173 of EGFR (Fazioli et al. 1991, Cohen et al. 1996, Chattopadhyay et al. 1999).

Literature References
PubMed ID Title Journal Year
10473558 The role of individual SH2 domains in mediating association of phospholipase C-gamma1 with the activated EGF receptor

Chattopadhyay, A, Vecchi, M, Ji, Q, Mernaugh, R, Carpenter, G

J Biol Chem 1999
8940074 The relationship between human epidermal growth-like factor receptor expression and cellular transformation in NIH3T3 cells

Cohen, BD, Kiener, PA, Green, JM, Foy, L, Fell, HP, Zhang, K

J Biol Chem 1996
1672440 The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency

Fazioli, F, Kim, UH, Rhee, SG, Molloy, CJ, Segatto, O, Di Fiore, PP

Mol Cell Biol 1991
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