RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4

Stable Identifier
R-HSA-1250383
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
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SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 activates RAS by mediating guanyl nucleotide exchange, which results in the activation of RAF/MAP kinase cascade (Kainulainen et al. 2000).
Literature References
PubMed ID Title Journal Year
10722704 A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis

Kainulainen, V, Sundvall, M, Määttä, JA, Santiestevan, E, Klagsbrun, M, Elenius, K

J Biol Chem 2000
Participants
Input
Output
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as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane]

Physical Entity
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Bos taurus)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Canis familiaris)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Danio rerio)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Drosophila melanogaster)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Gallus gallus)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Mus musculus)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Rattus norvegicus)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Sus scrofa)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2011-11-04)
Stern, DF  (2019-02-21)
Reviewed
Harris, RC  (2011-11-11)
Zeng, F  (2011-11-11)
Earp HS, 3rd  (2012-02-20)
Misior, AM  (2012-02-20)
Created
Orlic-Milacic, M  (2011-04-19)
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