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Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers
Stable Identifier
R-HSA-1250380
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB4 (Homo sapiens)
SHC1 events in ERBB4 signaling (Homo sapiens)
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Homo sapiens)
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Phosphorylated SHC1 bound to phosphorylated ERBB4 homodimers recruits GRB2:SOS1 complex (Kainulainen et al. 2000).
Literature References
PubMed ID
Title
Journal
Year
10722704
A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis
Santiestevan, E
,
Sundvall, M
,
Kainulainen, V
,
Määttä, JA
,
Elenius, K
,
Klagsbrun, M
J Biol Chem
2000
Participants
Input
GRB2-1:SOS1 [cytosol]
(Homo sapiens)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane]
(Homo sapiens)
Output
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane]
(Homo sapiens)
Participates
as an event of
SHC1 events in ERBB4 signaling (Homo sapiens)
Orthologous Events
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Bos taurus)
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Canis familiaris)
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Drosophila melanogaster)
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Gallus gallus)
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Mus musculus)
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Rattus norvegicus)
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Sus scrofa)
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2011-11-04)
Stern, DF (2019-02-21)
Reviewed
Zeng, F (2011-11-11)
Harris, RC (2011-11-11)
Earp HS, 3rd (2012-02-20)
Misior, AM (2012-02-20)
Created
Orlic-Milacic, M (2011-04-19)
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