p85 subunit of PI3K (PIK3R1) directly binds to phosphorylated ERBB4 CYT1 homodimers through docking tyrosine residues on either ERBB4 JM A CYT1 (tyrosine Y1056) or ERBB4 JM B CYT1 (tyrosine Y1046) isoform (Cohen et al. 1996, Kainulainen et al. 2000, Kaushansky et al. 2008).
Kainulainen, V, Sundvall, M, Määttä, JA, Santiestevan, E, Klagsbrun, M, Elenius, K
Kaushansky, A, Gordus, A, Budnik, BA, Lane, WS, Rush, J, MacBeath, G
Cohen, BD, Green, JM, Foy, L, Fell, HP
© 2021 Reactome