Membrane associated p85 subunit of PI3K (PIK3R1) binds to phosphorylated tyrosine residues of ERBB3 (Y1054, Y1197, Y1222, Y1224, Y1276 and Y1289) in complex with ERBB2. PIK3R1 is constitutively associated with the catalytic PI3K subunit p110 (PIK3CA). Binding of PIK3R1 to ERBB2:p-ERBB3 triggers a conformational change that activates PI3K (Yang et al. 2007, Junttila et al. 2009).
Yang, S, Raymond-Stintz, MA, Ying, W, Zhang, J, Lidke, DS, Steinberg, SL, Williams, L, Oliver, JM, Wilson, BS
Junttila, TT, Akita, RW, Parsons, K, Fields, C, Lewis Phillips, GD, Friedman, LS, Sampath, D, Sliwkowski, MX
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