Binding of PI3K to ERBB2:p-ERBB3 heterodimer

Stable Identifier
R-HSA-1250189
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
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Binding of PI3K to ERBB2:p-ERBB3 heterodimer
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Membrane associated p85 subunit of PI3K (PIK3R1) binds to phosphorylated tyrosine residues of ERBB3 (Y1054, Y1197, Y1222, Y1224, Y1276 and Y1289) in complex with ERBB2. PIK3R1 is constitutively associated with the catalytic PI3K subunit p110 (PIK3CA). Binding of PIK3R1 to ERBB2:p-ERBB3 triggers a conformational change that activates PI3K (Yang et al. 2007, Junttila et al. 2009).

Literature References
PubMed ID Title Journal Year
19411071 Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941

Junttila, TT, Fields, C, Sliwkowski, MX, Lewis Phillips, GD, Sampath, D, Friedman, LS, Parsons, K, Akita, RW

Cancer Cell 2009
17652160 Mapping ErbB receptors on breast cancer cell membranes during signal transduction

Zhang, J, Yang, S, Steinberg, SL, Wilson, BS, Oliver, JM, Ying, W, Williams, L, Raymond-Stintz, MA, Lidke, DS

J Cell Sci 2007
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Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-04-14)
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