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NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane]
Stable Identifier
R-HSA-1248749
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
ERBB2 Activates PTK6 Signaling (Homo sapiens)
Activated ERBB2 binds PTK6 (BRK) (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 promotes PTK6 autophosphorylation (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
Downregulation of ERBB2 signaling (Homo sapiens)
Downregulation of ERBB2:ERBB3 signaling (Homo sapiens)
RNF41 binds neuregulin-activated ERBB3 (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
RNF41 ubiquitinates activated ERBB3 (Homo sapiens)
NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers:MATK [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Homo sapiens)
Heterodimers of p-ERBB2 dephosphorylated at Y1248 [plasma membrane] (Homo sapiens)
Phosphorylated p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 Activates PTK6 Signaling (Homo sapiens)
Activated ERBB2 binds PTK6 (BRK) (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 promotes PTK6 autophosphorylation (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers:PTK6 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
ERBB2 Regulates Cell Motility (Homo sapiens)
MEMO1 binds RHOA:GTP:DIAPH1 (Homo sapiens)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2 heterodimers bind MEMO1 (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
GRB7 events in ERBB2 signaling (Homo sapiens)
GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-ERBB2:GRB7 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
PI3K events in ERBB2 signaling (Homo sapiens)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Homo sapiens)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
SHC1 events in ERBB2 signaling (Homo sapiens)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers (Homo sapiens)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers (Homo sapiens)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
SHC1 binds phosphorylated ERBB2 heterodimers (Homo sapiens)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
SHC1 phosphorylation by ERBB2 heterodimers (Homo sapiens)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Homo sapiens)
p-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] (Homo sapiens)
Participants
components
NRG1/2:p-10Y-ERBB3 [plasma membrane]
(Homo sapiens)
p-Y,Y877-ERBB2 [plasma membrane]
(Homo sapiens)
Participates
as a member of
Phosphorylated p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
as a candidate of
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Homo sapiens)
Inferred To
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane]
(Bos taurus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane]
(Canis familiaris)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane]
(Danio rerio)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane]
(Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane]
(Gallus gallus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane]
(Mus musculus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane]
(Rattus norvegicus)
NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane]
(Sus scrofa)
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