EGFRvIII mutant binds chaperone proteins HSP90 and CDC37.

Stable Identifier
R-HSA-1247999
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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EGFRvIII mutant binds chaperone proteins HSP90 and CDC37.
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Association of EGFRvIII mutant with HSP90 chaperone protein and its co-chaperone CDC37 is necessary for the proper functioning of mutant EGFR.

Literature References
PubMed ID Title Journal Year
12471035 Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII

Kelly, JF, Lavictoire, SJ, Lorimer, IA, Parolin, DA, Klimowicz, AC

J Biol Chem 2003
Participants
Input
Output
Participates
as an event of
Functional status

Gain of function of EGFRvIII [plasma membrane]

Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Greulich, H  (2011-11-15)
Savas, S  (2011-11-15)
Created
Orlic-Milacic, M  (2011-04-09)
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