Activation of p38 MAPK

Stable Identifier
R-HSA-1247960
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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p38 MAPK has 4 representative isoforms in humans, p38 alpha (Han et al. 1993), p38-beta (Jiang et al. 1996), p38-gamma (Lechner et al. 1996) and p38-delta (Hu et al. 1999). All are activated by phosphorylation on a canonical TxY motif by the dual-specificity kinase MKK6, which displays minimal substrate selectivity amongst the p38 isoforms (Zarubin & Han, 2005). p38 alpha and gamma are also activated by MKK3.

Literature References
PubMed ID Title Journal Year
9430721 Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6

Enslen, H, Raingeaud, J, Davis, RJ

J Biol Chem 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
MAP kinase kinase activity of p-S207,T211-MAP2K6 [cytosol]
Physical Entity
Activity
Orthologous Events
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