Activation of p38 MAPK

Stable Identifier
R-HSA-1247960
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Activation of p38 MAPK
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p38 MAPK has 4 representative isoforms in humans, p38 alpha (Han et al. 1993), p38-beta (Jiang et al. 1996), p38-gamma (Lechner et al. 1996) and p38-delta (Hu et al. 1999). All are activated by phosphorylation on a canonical TxY motif by the dual-specificity kinase MKK6, which displays minimal substrate selectivity amongst the p38 isoforms (Zarubin & Han, 2005). p38 alpha and gamma are also activated by MKK3.

Literature References
PubMed ID Title Journal Year
9430721 Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6

Enslen, H, Raingeaud, J, Davis, RJ

J Biol Chem 1998
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
MAP kinase kinase activity of p-S207,T211-MAP2K6 [cytosol]
Physical Entity
p-S207,T211-MAP2K6 [cytosol]
Activity
MAP kinase kinase activity (0004708)
Orthologous Events
Activation of p38 MAPK (Caenorhabditis elegans)
Activation of p38 MAPK (Danio rerio)
Activation of p38 MAPK (Drosophila melanogaster)
Activation of p38 MAPK (Mus musculus)
Activation of p38 MAPK (Rattus norvegicus)
Activation of p38 MAPK (Saccharomyces cerevisiae)
Activation of p38 MAPK (Schizosaccharomyces pombe)
Activation of p38 MAPK (Sus scrofa)
Activation of p38 MAPK (Xenopus tropicalis)
Authored
Jupe, S  (2011-04-08)
Reviewed
Kufer, TA  (2011-04-28)
Rittinger, K  (2011-06-06)
Wong, E  (2011-06-06)
Created
Jupe, S  (2011-04-08)
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